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Regulation of cells function by light technology

Research Project

Project/Area Number 21687011
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionOsaka University

Principal Investigator

KUSHIBIKI Toshihiro  大阪大学, 臨床医工学融合研究教育センター, 招へい准教授 (30403158)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords光 / レーザー / 細胞 / 機能制御 / 光線力学療法 / NF-kappaB / p38MAPK / 国際研究者交流 / アメリカ / サイトカイン / 光生物 / 幹細胞 / 細胞機能制御 / ヒスタミン / がん / 免疫応答
Research Abstract

The regulations of cells function by using noninvasive methods are the effective tools not only for treatment and prevent diseases but also basic biomedical researches. The objective of this research is the application of laser and light technology for the regulation of cells function. In the results, I found that intracellular reactive oxygen species were increased after laser(wavelength : 405 nm) irradiation, following NF-κB and MAPK phosphorylation. These results suggest that the laser light is one of the effective tools for the regulation of cells function.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Photodynamic therapy induces interleukin secretion from dendritic cells2010

    • Author(s)
      Kushibiki T, Tajiri T, Tomioka Y, Awazu K
    • Journal Title

      Int J Clin Exp Med

      Volume: 3巻 Pages: 110-114

    • URL

      http://www.ijcem.com/files/IJCEM1002002.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic therapy induces microRNA-210 and-296 expression in Hela cells2010

    • Author(s)
      Kushibiki T
    • Journal Title

      J Biophotonics

      Volume: 3巻 Issue: 5-6 Pages: 368-372

    • DOI

      10.1002/jbio.200900082

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic therapy induces interleukin secretion from dendritic cells2010

    • Author(s)
      櫛引俊宏, ほか
    • Journal Title

      International Journal of Clinical and Experimental Medicine

      Volume: 3 Pages: 110-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 光技術を用いた新しい細胞機能制御法2011

    • Author(s)
      櫛引俊宏
    • Organizer
      第178回バイオを論じる会
    • Place of Presentation
      防衛医科大学校
    • Year and Date
      2011-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 光技術を用いた新しい細胞機能制御法2011

    • Author(s)
      櫛引俊宏
    • Organizer
      第178回バイオを論じる会
    • Place of Presentation
      防衛医科大学校(招待講演)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 波長405nm光がおよぼす生物作2010

    • Author(s)
      櫛引俊宏
    • Organizer
      第22回日本レーザー治療学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] 光がおよぼす生物作用2010

    • Author(s)
      櫛引俊宏
    • Organizer
      第20回日本光線力学学会
    • Place of Presentation
      福井県福井市
    • Related Report
      2011 Final Research Report
  • [Presentation] 波長405nm光がおよぼす生物作用2010

    • Author(s)
      櫛引俊宏
    • Organizer
      第22回日本レーザー治療学会
    • Place of Presentation
      神奈川県横浜市(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光がおよぼす生物作用2010

    • Author(s)
      櫛引俊宏
    • Organizer
      第20回日本光線力学学会
    • Place of Presentation
      福井県福井市(招待講演)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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