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X-ray structural analysis of the vault with a molecular weight of 10 MDa.

Research Project

Project/Area Number 21687012
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionOsaka University

Principal Investigator

TANAKA Hideaki  大阪大学, 蛋白質研究所, 助教 (40346169)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywordsボルト / X線結晶構造解析 / 自然免疫 / 脂質ラフト / 生体超分子複合体 / 核酸-タンパク質複合体 / vault / 自然免疫反応
Research Abstract

I have obtained high quality crystals of the vault which diffracted x-rays at 2. 8Åresolution on beam line BL44XU at the SPring-8.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 Other

All Journal Article (14 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] ミニレビュー「全立体構造決定から切り開く謎の巨大粒子ボルトの機能解明」2011

    • Author(s)
      田中秀明、加藤公児、住澤知之、山下栄樹
    • Journal Title

      生化学

      Volume: 83 Pages: 392-395

    • Related Report
      2011 Final Research Report
  • [Journal Article] 全立体構造決定から切り開く謎の巨大粒子ボルトの機能解明2011

    • Author(s)
      田中秀明、加藤公児、住澤知之、山下栄樹
    • Journal Title

      生化学

      Volume: 83 Pages: 392-395

    • NAID

      10029068456

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Journal Article] 分子量が1000万にも及ぶ生体内巨大分子に対する構造解析2009

    • Author(s)
      山下栄樹、加藤公児、田中秀明
    • Journal Title

      日本放射光学会誌

      Volume: 22 Pages: 284-291

    • NAID

      10025445461

    • Related Report
      2011 Final Research Report
  • [Journal Article] 最近の研究から「分子量約1000万の巨大粒子vaultのX線結晶構造」2009

    • Author(s)
      田中秀明、加藤公児
    • Journal Title

      日本結晶学会誌

      Volume: 51 Pages: 189-194

    • Related Report
      2011 Final Research Report
  • [Journal Article] Short Review「細胞内にある最大の核酸-蛋白質複合体vaultのX線結晶構造」2009

    • Author(s)
      加藤公児、田中秀明
    • Journal Title

      蛋白質核酸酵素

      Volume: 54 Pages: 1159-1165

    • Related Report
      2011 Final Research Report
  • [Journal Article] カレントトピックス「巨大粒子vaultの形から見えてきたこと」2009

    • Author(s)
      住澤知之、田中秀明
    • Journal Title

      実験医学

      Volume: 27 Pages: 1751-1754

    • Related Report
      2011 Final Research Report
  • [Journal Article] トピックス新進気鋭シリーズ「分子量約1000万の巨大粒子vaultの全体構造決定から機能解明に迫る」2009

    • Author(s)
      田中秀明
    • Journal Title

      生物物理

      Volume: 49 Pages: 302-303

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Structure of Rat Liver Vault at 3. 5 Angstrom Resolution2009

    • Author(s)
      Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M and Tsukihara T
    • Journal Title

      ANNUAL REPORT OF OSAKA UNIVERSITY 2008-2009

      Volume: 100 Selected Papers Pages: 67-67

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Structure of Rat Liver Vault at 3. 5 Angstrom Resolution2009

    • Author(s)
      Kato K, Tanaka H and Tsukihara T
    • Journal Title

      SPring-8 Research Frontiers 2009

      Pages: 28-29

    • Related Report
      2011 Final Research Report
  • [Journal Article] 分子量が1000万にも及ぶ生体内巨大分子に対する構造解析2009

    • Author(s)
      山下栄樹、加藤公児、田中秀明
    • Journal Title

      日本放射光学会誌 22(6)

      Pages: 284-291

    • NAID

      10025445461

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 分子量約1000万の巨大粒子vaultの全体構造決定から機能解明に迫る2009

    • Author(s)
      田中秀明
    • Journal Title

      日本生物物理学会誌 49(6)

      Pages: 302-303

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 分子量約1000万の巨大粒子巨大vaultのX線結晶構造2009

    • Author(s)
      田中秀明、加藤公児、山下栄樹
    • Journal Title

      日本結晶学会誌 51(3)

      Pages: 189-194

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ラット肝由来の巨大な核酸タンパク質複合体vaultのX線結晶構造2009

    • Author(s)
      住澤知之、加藤公児、田中秀明
    • Journal Title

      実験医学 27(11)

      Pages: 1751-1754

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 細胞内にある巨大な核酸-蛋白質複合体VaultのX線結晶構造2009

    • Author(s)
      田中秀明、加藤公児、山下栄樹
    • Journal Title

      蛋白質 核酸 酵素 54(9)

      Pages: 1159-1165

    • NAID

      40016708053

    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure determination of rat vault, a large nucleoprotein complex at 3. 5A resolution2011

    • Author(s)
      Tanaka H
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Structure determination of rat vault, a large nucleoprotein complex at 3.5Å resolution2011

    • Author(s)
      田中秀明
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学(兵庫県)(招待講演)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] The self-assembly mechanism of the vault2011

    • Author(s)
      藤田千鶴子、田中秀明、月原冨武
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      大阪府
    • Year and Date
      2011-06-07
    • Related Report
      2011 Final Research Report
  • [Presentation] The mechanisms of self-assembly of the vault2011

    • Author(s)
      Tanaka H
    • Organizer
      the largest cytoplasmic ribonucleo-protein complex. XXII Congress and General Assembly of the International Union of Crystallography(IUCr2011)
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] The mechanisms of self-assembly of the vault, the largest cytoplasmic ribonucleo-protein complex2011

    • Author(s)
      田中秀明
    • Organizer
      IUCr2011
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] 謎の巨大分子ボルトの全立体構造情報の利用~機能解明とDDSへの応用を目指して~2010

    • Author(s)
      田中秀明
    • Organizer
      SENRI(Seminar for Enchaining of Research & Industry)の会
    • Place of Presentation
      大阪府
    • Year and Date
      2010-12-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 謎の巨大分子ボルトの全立体構造情報の利用~機能解明とDDSへの応用を目指して~2010

    • Author(s)
      田中秀明
    • Organizer
      SENRI (Seminar for Enchaining of Research & Industry)の会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)(招待講演)
    • Year and Date
      2010-12-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] The mechanisms of self-assembly of the vault : the largest cytoplasmic ribonucleo protein complex2010

    • Author(s)
      田中秀明
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii Convention Center, USA
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] X-ray crystal structure of rat vault, a large nucleoprotein complex at 3.5Å resolution.2010

    • Author(s)
      田中秀明
    • Organizer
      Proceedings of the International Symposium on New Drug Development
    • Place of Presentation
      Chungbuk National University, Korea(招待講演)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] X-ray crystal structure of rat vault, a large nucleoprotein complex at 3. 5A resolution2010

    • Author(s)
      Tanaka H
    • Organizer
      International Symposium at Chungbuk National University
    • Place of Presentation
      Chungbuk, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] 分子量約1000万の核酸-タンパク質複合体vaultのX線結晶構造解析2009

    • Author(s)
      田中秀明
    • Organizer
      日本結晶学会
    • Place of Presentation
      関西学院大学(兵庫県)
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分子量約1000万の核酸ータンパク質複合体vaultのX線結晶構造解析2009

    • Author(s)
      田中秀明
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      兵庫県
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] The mechanisms of self-assembly of the vault : the largest cytoplasmic ribonucleoprotein complex

    • Author(s)
      Tanaka H
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2011 Final Research Report
  • [Remarks] ボルトのイメージ図、ムービーなど_

    • URL

      http://www.protein.osaka-u.ac.jp/crystallography/mvp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/olabb/tsukihara/mvp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/olabb/tsukihara/mvp/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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