| Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Research Abstract |
Most cancers arise from a single cell of origin in an epithelial sheet. Therefore, a newly emerged oncogenic cell in the epithelium has to confront anti-tumor selective pressures in the host tissue. However, the mechanisms by which surrounding normal tissue exerts anti-tumor effects against oncogenically transformed cells are poorly understood. Using the Drosophila genetics, we found that normal epithelial cells activate JNK-dependent engulfment pathway in response to the emergence of oncogenic polarity-deficient cells, thereby eliminating oncogenic neighbors through cell competition.
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