| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2009: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
|---|
| Research Abstract |
It was demonstrated that ABCG_1 and ABCG_4 , a lipid transporter, suppress amyloidβsecretion and that ABCG_1 stimulates axonal extension of central nervous neurons. Analysis of purified proteins suggested that ABCG_1 transports cholesterol and choline phospholipid, while ABCG_4 transports cholesterol. It was also demonstrated that ABCG_1 and ABCG_4 distribute to distinct domains on the plasma membrane and transport lipid by modulating the domain structures.
|
