| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Research Abstract |
We discovered the newly molecular mechanisms of tumor-related factors. We also established that the expression system of cell-permeable tumor suppressors for the protein therapy of tumor suppression.
(1) Identification of "Stabilon" motif that is significant for protein stability of transcription factor DP-1 concerned with tumor growth.
(2) Discovery of the suppression of TRIP6-mediated LPA signal transduction by SOCS7 and new isoforms of TRIP6.
(3) Establishment of E. coli. expression system of cell-permeable RARa, SOCS-3, p53 and SOCS-2.
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