Species-level Diversity of Epigenetic Regulation for Brain Function Mediated by Non-coding RNA
| Project/Area Number |
21688021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2009: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 非コードRNA / DNAメチル化 / 生物多様性 / エピジェネティック制御 / 脳 |
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| Research Abstract |
Brains of mammalian species mutually differ in the morphology and functions, even those of human and chimpanzee that share~ 98% nucleotide homologies. We have reported promoter-associated noncoding RNA(pancRNA) that acts to activate downstream gene expression through DNA demethylation. This study shows that DNA elements inserted into gene promoter regions of a certain species have provided the templates for species-specific panc RNAs.
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Report
(4 results)
Research Products
(29 results)
