| Budget Amount *help |
¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Research Abstract |
Callipeltins are linear-and cyclic depsi-peptides isolated from marine sponge by Zampella's group. These molecules were reported to exhibit anti-HIV activity and cytotoxicity against various tumor cell lines. In the course of our recent research regarding the synthetic study of cyclic depsipeptides, we conducted studies on the synthesis of callipeltins supposed to be efficient structures for CCR5 inhibitors as anti-HIV drugs or anti-cancer agents. In the present study, we performed the stereoselective synthesis of several unusual amino acids and solid phase synthesis of callipeltin E, M and B on Fmoc-strategy. In addition, we evaluated the cytotoxicity against the Hela cell line.
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