| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Research Abstract |
We previously showed that Akr1 is involved in the reduction of methylmercury toxicity in budding yeast. In the present study, we found that the palmitoylation of Meh1 by Akr1 is essential for the protective effect of Meh1 against methylmercury toxicity. We also found that palmitoylation of Meh1 is important for its localization into the vacuolar membrane and its function to reduce methylmercury toxicity as a component of the EGO complex. Furthermore, the EGO complex may be involved in reduction of methylmercury toxicity through suppressing the abnormal vacuoles form caused by methylmercury.
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