Central molecular mechanism of autonomic actions by hormone derived from adipose tissue

• Project/Area Number: 21689008
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Ritsumeikan University
• Principal Investigator: TANIDA Mamoru 立命館大学, 生命科学部, 助教 (70512309)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
• Keywords: レプチン / 肥満 / 自律神経 / 視床下部 / 電気生理 / 高血圧 / 交感神経活動 / 副交感神経活動 / in vivoノックダウン / アディポネクチン

Research Abstract

We strongly noted metabolic syndrome having a high mortality in Japan. Then, in present study, we examined leptin and adiponectin which act in the brain and play an important role in feeding and homeostasis with using animal autonomic recording system. We newly showed that central mechanism of leptin or adiponectn in autonomic regulation, hoping it will be applied to new drag research.

Research Products

• [Journal Article] Role of L :-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats ; involvement of the circadian clock and histamine (2012)
  • Author(s): Nagai K, Tanida M, Niijima A, Tsuruoka N, Kiso Y, Horii Y, Shen J, Okumura N
  • Journal Title: Amino Acids Volume: (in press)
  • Peer Reviewed
• [Journal Article] Brain insulin resistance accelerates As fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes (2012)
  • Author(s): Yamamoto N, Matsubara T, Sobue K, Tanida M, Kasahara R, Naruse K, Taniura H, Sato T, Suzuki K
  • Journal Title: Journal of Neurochemistry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Brain insulin resistance accelerates Ass fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes (2012)
  • Author(s): Yamamoto N, Matsubara T, Sobue K, Tanida M, Kasahara R, Naruse K, Taniura H, Sato T, Suzuki K
  • Journal Title: Journal of Neurochemistry Volume: (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Role of L : -carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats : involvement of the circadian clock and histamine (2012)
  • Author(s): Nagai K, Tanida M, Niijima A, Tsuruoka N, Kiso Y, Horii Y, Shen J, Okumura N
  • Journal Title: Amino Acids Volume: (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Central AMP-activated protein kinase affects sympathetic nerve activity in rats (2011)
  • Author(s): Tanida M, Yamamoto N
  • Journal Title: Neuroscience Letters Volume: 503 Pages: 167-170
  • Peer Reviewed
• [Journal Article] Electrophysiological analysis of the mechanism of autonomic action by Lactobacilli (2011)
  • Author(s): Tanida M, Nagai, K
  • Journal Title: Bioscience and Microflora Volume: 30(4) Pages: 99-109
  • NAID: 10030171368
  • Peer Reviewed
• [Journal Article] Nesfatin-1 stimulates renal sympathetic nerve activity in rats (2011)
  • Author(s): Tanida M, Mori M
  • Journal Title: Neuroreport Volume: 22 Pages: 309-312
  • Peer Reviewed
• [Journal Article] The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide (2011)
  • Author(s): Tanida M, Shintani N, Hashimoto H
  • Journal Title: Neuroscience Research Volume: 70 Pages: 55-61
  • Peer Reviewed
• [Journal Article] Effects of intragastric Injection of Glutamate on Efferent sympathetic nerve activity in Rats (2011)
  • Author(s): Tanida M, Satomi J
  • Journal Title: Neuroscience Letters Volume: 491 Pages: 211-215
  • Peer Reviewed
• [Journal Article] PACAP is Implicated in the Stress Axes (2011)
  • Author(s): Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A
  • Journal Title: Current Pharmaceutical Design Volume: 17/10 Pages: 985-989
  • Peer Reviewed
• [Journal Article] PACAP centrally mediates emotional stress-induced corticosterone responses in mice (2011)
  • Author(s): Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri Y, Hazama K, Ogata K, Hashimoto H, Baba A
  • Journal Title: Stress Volume: 4 Pages: 368-75
  • Peer Reviewed
• [Journal Article] Skin application of urea? containing cream affected cutaneous arterial sympathetic nerve activity, blood flow, and water evaporation (2011)
  • Author(s): Horii Y, Tanida M, Shen J, Fujisaki Y, Fuyuki R, Hashimoto K, Niijima A, Nakashima T, Nagai K
  • Journal Title: Skin Research and Technology Volume: 117/1 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Central AMP-activated protein kinase affects sympathetic nerve activity in rats. 503,, (2011) (2011)
  • Author(s): Tanida M, Yamamoto N
  • Journal Title: Neuroscience Letters Volume: 503 Pages: 167-170
  • Peer Reviewed
• [Journal Article] Electrophysiological analysis of the mechanism of autonomic action by Lactobacilli (2011)
  • Author(s): Tanida M., Nagai K.
  • Journal Title: Bioscience and Microflora Volume: 30 Pages: 99-109
  • NAID: 10030171368
  • Peer Reviewed
• [Journal Article] Skin application of urea-containing cream affected cutaneous arterial sympathetic nerve activity, blood flow, and water evaporation. (2011)
  • Author(s): Horii Y, Tanida M, Shen J, Fujisaki Y, Fuyuki R, Hashimoto K, Niijima A, Nakashima T, Nagai K
  • Journal Title: Skin Research and Technology Volume: 17 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Effects of intragastric injection of glutamate on efferent sympathetic nerve activity in rats. (2011)
  • Author(s): Tanida M, Satomi J.
  • Journal Title: Neuroscience Letters Volume: 491 Pages: 211-215
  • Peer Reviewed
• [Journal Article] Effects of anserine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats (2010)
  • Author(s): Tanida M, Shen J, Kubomura D, Nagai K
  • Journal Title: Physiological Research Volume: 59 Pages: 177-85
  • Peer Reviewed
• [Journal Article] Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide (2010)
  • Author(s): Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai
  • Journal Title: Regulatory Peptides Volume: 161 Pages: 73-80
  • Peer Reviewed
• [Journal Article] Effect of an intraduodenal injection of fat on the activities of the adrenal efferent sympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats (2010)
  • Author(s): Matsumura S, Eguchi A, Kitabayashi N, Tanida M, Shen J, Horii Y, Nagai K, Tsuzuki S, Inoue K, Fushiki T
  • Journal Title: Neuroscience Research Volume: 67 Pages: 236-44
  • Peer Reviewed
• [Journal Article] Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight (2010)
  • Author(s): Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K
  • Journal Title: Neuroscience Letters Volume: 479 Pages: 181-186
  • Peer Reviewed
• [Journal Article] Effects of anserine on the renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. (2010)
  • Author(s): Tanida M, Shen J, Kubomura D, Nagai K.
  • Journal Title: Physiological Research Volume: 59 Pages: 177-185
  • Peer Reviewed
• [Journal Article] Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide. (2010)
  • Author(s): Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K.
  • Journal Title: Regulatory peptides Volume: 161 Pages: 73-80
  • Peer Reviewed
• [Journal Article] Effect of an intraduodenal injection of fat on the activities of the adrenal efferent ympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats. (2010)
  • Author(s): Matsumura S, Eguchi A, Kitabayashi N, Tanida M, Shen J, Horii Y, Nagai K, Tsuzuki S, Inoue K, Fushiki T.
  • Journal Title: Neuroscience Research Volume: 67 Pages: 236-244
  • Peer Reviewed
• [Journal Article] Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight. (2010)
  • Author(s): Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K
  • Journal Title: Neuroscience Letters Volume: 479 Pages: 181-186
  • Peer Reviewed
• [Journal Article] 筋肉からの代謝・自律神経ネットワークを介した血圧調節 (2010)
  • Author(s): 永井克也、谷田守、新島旭、奥村宣明
  • Journal Title: 血圧 Volume: 17 Pages: 854-859
  • Peer Reviewed
• [Journal Article] Effects of flavangenol on autonomic nerve activities and dietary body weight gain in rats, Bioscience (2009)
  • Author(s): Tanida M, Tsuruoka N, Shen J, Horii Y, Beppu Y, Kiso Y, Nagai K
  • Journal Title: Biotechnology and Biochemistry Volume: 73 Pages: 2374-2378
  • Peer Reviewed
• [Journal Article] Autonomic and cardiovascular effects of central neuromedin U in rats (2009)
  • Author(s): Tanida M, Satomi J, Nagai K
  • Journal Title: Physiology & Behavior Volume: 96 Pages: 282-288
  • Peer Reviewed
• [Journal Article] Effect of the culture extract of Lentinus edodes mycelia on splenic sympathetic activity and cancer cell proliferation (2009)
  • Author(s): Shen J, Tanida M, Fujisaki Y, Horii Y, Hashimoto K, Nagai K
  • Journal Title: Autonomic Neuroscience-Basic and Clinical Volume: 28 Pages: 50-54
  • Peer Reviewed
• [Journal Article] Effects of auditory stimulation on parasympathetic nerve activity in urethane-anesthetized rats (2009)
  • Author(s): Nakamura T, Tanida M, Niijima A, Nagai K
  • Journal Title: In Vivo Volume: 23 Pages: 415-419
  • Peer Reviewed
• [Journal Article] Effect of 4G-alpha-glucopyranosyl hesperidin on brown fat adipose tissue-and cutaneous-sympathetic nerve activity and peripheral body temperature (2009)
  • Author(s): Shen J, Nakamura H, Fujisaki Y, Tanida M, Horii Y, Fuyuki R, Takumi H, Shiraishi K, Kometani T, Nagai K
  • Journal Title: Neuroscience Letters Volume: 461 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice : amelioration by the atypical antipsychotic risperidone (2009)
  • Author(s): Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A
  • Journal Title: Journal of Neurochemistry Volume: 110 Pages: 595-602
  • Peer Reviewed
• [Journal Article] Possible role of the histaminergic system in autonomic and cardiovascular responses to neuropeptide Y (2009)
  • Author(s): 谷田守, 沈嬌, 永井克也
  • Journal Title: Neuropeptide 43 Pages: 21-29
  • Peer Reviewed
• [Journal Article] Autonomic and cardiovascular effects of central neuromedin U in rats (2009)
  • Author(s): Tanida M, Satomi J, Nagai K.
  • Journal Title: Physiology & Behavior 96 Pages: 282-288
  • Peer Reviewed
• [Journal Article] Effect of the culture extract of Lentinus edodes mycelia on splenic sympathetic activity and cancer cell proliferation (2009)
  • Author(s): Shen J, Tanida M, Fujisaki Y, Horii Y, Hashimoto K, Nagai K.
  • Journal Title: Autonomic Neuroscience-Basic and Clinical 28 Pages: 50-54
  • Peer Reviewed
• [Journal Article] Effects of auditory stimulation on parasympathetic nerve activity in urethane-anesthetized rats (2009)
  • Author(s): Nakamura T, Tanida M, Niijima A, Nagai K.
  • Journal Title: In Vivo 23 Pages: 415-419
  • Peer Reviewed
• [Journal Article] Effect of 4G-alpha-glucopyranosyl hesperidin on brown fat adipose tissue-and cutaneous-sympathetic nerve activity and peripheral body temperature (2009)
  • Author(s): Shen J, Nakamura H, Fujisaki Y, Tanida M, Horii Y, Fuyuki R, Takumi H, Shiraishi K, Kometani T, Nagai K.
  • Journal Title: Neuroscience Letters 461 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice : a melioration by the atypical antipsychotic risperidone (2009)
  • Author(s): Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A.
  • Journal Title: Journal of Neurochemistry 110 Pages: 595-602
  • Peer Reviewed
• [Journal Article] Effects of flavangenol on autonomic nerve activities and dietary body weight gain in rats (2009)
  • Author(s): Tanida M, Tsuruoka N, Shen J, Horii Y, Beppu Y, Kiso Y, Nagai K.
  • Journal Title: Biosci Biotechnol Biochem. 73 Pages: 2374-2378
  • NAID: 10027547410
  • Peer Reviewed
• [Journal Article] ユズ(Citrus junos)精油の匂い刺激による自律神経制御を介したエネルギー代謝への影響 (2009)
  • Author(s): 熊谷千津、堀井裕子、沈嬌、永井克也、谷田守、新島旭、岡田嘉仁、奥山徹、沢村正義
  • Journal Title: AROMA RESEARCH 38 Pages: 156-161
  • Peer Reviewed
• [Journal Article] 乳酸菌の腸内投与による自律神経活動と生理機能の変化 (2009)
  • Author(s): 永井克也、谷田守、福島洋一、山野俊彦、新島旭、前田景子、奥村宣明、堀井裕子
  • Journal Title: 腸内細菌学雑誌 23 Pages: 209-216
  • NAID: 10027119273
  • Peer Reviewed
• [Presentation] PACAPノックアウトマウスの摂食及び交感神経活動へのレプチン投与効果 (2012)
  • Author(s): 谷田守、早田敦子、新谷紀人、橋本均
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] 視床下部AMPキナーゼによる腎臓及び肝臓を支配する自律神経調節 (2011)
  • Author(s): 谷田守
  • Organizer: 第88回日本生理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-03-28
• [Presentation] Nesfatin-1による交感神経活動調節の脳内分子メカニズム解析 (2011)
  • Author(s): 谷田守、森昌朋
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] PACAPによる自律神経調節 (2010)
  • Author(s): 谷田守、新谷紀人、橋本均
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡市民文化ホール(岩手県)
  • Year and Date: 2010-05-20
• [Presentation] PACAPによる自律神経作用 (2010)
  • Author(s): 谷田守、新谷紀人、畑中道賢、橋本均、馬場明道
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡市民文化ホール 岩手県
  • Year and Date: 2010-05-19
• [Presentation] ラット白色脂肪交感神経の同定に関する電気生理学的解析 (2009)
  • Author(s): 谷田守
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松(静岡県)
  • Year and Date: 2009-10-09
• [Presentation] ラット白色脂肪交感神経の同定に関する電気生理学的解析 (2009)
  • Author(s): 谷田守
  • Organizer: 日本肥満学会
  • Place of Presentation: アクトシティ浜松(静岡県)
  • Year and Date: 2009-10-09
• [Presentation] Autonomic, cardiovascular and thermoregulatory responses to central neropeptide Y or neuromedin U in rats (2009)
  • Author(s): 谷田守
  • Organizer: Experimental Biology 2009
  • Place of Presentation: 米国・ニューオリンズ
  • Year and Date: 2009-04-20
• [Presentation] Autonomic, cardiovascular and thermoregulatory responses to central neropeptide Y or neuromedin U in rats (2009)
  • Author(s): Tanida M
  • Organizer: Experimental Biology 2009
  • Place of Presentation: ニューオリンズ・米国
• [Book] Evidence-based Anticancer Materia Medica (2011)
  • Author(s): J.Shen, J-F.Yao, M.Tanida, Y.Horii, K.Nagai
  • Publisher: Springer, Science+Business
• [Remarks]
  • URL: http://research-db.ritsumei.ac.jp/Profiles/47/0004643/profile.html
• [Remarks]
  • URL: http://research-db.ritsumei.ac.jp/Profiles/47/0004643/profile.html