Revaluation of contraction band necrosis as a marker for cardiac sudden death
Project/Area Number |
21689020
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Legal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
SHINTANI Kaori (ISHIDA Kaori) 東京大学, 大学院・医学系研究科, 講師 (50345047)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
|
Keywords | 心臓突然死 / 収縮帯壊死 / 小胞体 / ミトコンドリア / カルシウム / フォスフォランバン / 心筋梗塞 / 小胞体カルシウム / カルシニューリン |
Research Abstract |
Contraction bands(CBs) are formed in early phase of myocardial infarction and have been believed to cause myocardial infarction. In rat model of coronary occlusion, the causality of CB for myocardial infarction was investigated. In ischemia-reperfusion, phospholanban(PLN), a regulatory protein of SR calcium uptake, was dephosphorylated, thereby causing formation of CBs. In vivo injection of anti-PLN antibody enhanced SR calcium uptake and inhibited the CB formation. On the other hand, the antibody induced mPTP opening through mitochondrial calcium overload and enlarged the region of myocardial infarction. These results indicate that mPTP opening, but not CB formation, is pivotal for the development of myocardial infarction.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] 心筋収縮帯と心筋梗塞の関連性2011
Author(s)
新谷香, 黒田亮平, 廣瀬泉, 吉田謙一
Organizer
第95次日本法医学会学術全国集会
Place of Presentation
コラッセふくしま(福島県福島市)
Year and Date
2011-06-17
Related Report
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