• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Revaluation of contraction band necrosis as a marker for cardiac sudden death

Research Project

Project/Area Number 21689020
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

SHINTANI Kaori (ISHIDA Kaori)  東京大学, 大学院・医学系研究科, 講師 (50345047)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords心臓突然死 / 収縮帯壊死 / 小胞体 / ミトコンドリア / カルシウム / フォスフォランバン / 心筋梗塞 / 小胞体カルシウム / カルシニューリン
Research Abstract

Contraction bands(CBs) are formed in early phase of myocardial infarction and have been believed to cause myocardial infarction. In rat model of coronary occlusion, the causality of CB for myocardial infarction was investigated. In ischemia-reperfusion, phospholanban(PLN), a regulatory protein of SR calcium uptake, was dephosphorylated, thereby causing formation of CBs. In vivo injection of anti-PLN antibody enhanced SR calcium uptake and inhibited the CB formation. On the other hand, the antibody induced mPTP opening through mitochondrial calcium overload and enlarged the region of myocardial infarction. These results indicate that mPTP opening, but not CB formation, is pivotal for the development of myocardial infarction.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] Ischemia-reperfusion induces myocardial infarction through mitochondrial Ca^<2+> overload2012

    • Author(s)
      Shintani-Ishida K, Inui M, Yoshida K
    • Journal Title

      J Mol Cell Cardiol

      Volume: (掲載確定印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia induces phospholamban dephosphorylation via activation of calcineurin2011

    • Author(s)
      Shintani-Ishida K, Yoshida K
    • Journal Title

      PKC-α, and protein phosphatase 1, thereby inducing calcium overload in reperfusion. Biochim. Biophys

      Volume: 1812 Issue: 7 Pages: 743-751

    • DOI

      10.1016/j.bbadis.2011.03.014

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia induces phospholamban dephosphorylation via activation of calcineurin, PKC-α, and protein phosphatase 1, thereby inducing calcium overload in reperfusion2011

    • Author(s)
      Shintani-Ishida K, Yoshida K
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: (掲載確定(印刷中))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restraint Stress Induces Connexin-43 Translocation via &alpha;-Adrenoceptors in Rat Heart2010

    • Author(s)
      Unuma K, Shintani-Ishida K, et al
    • Journal Title

      Circulation Journal

      Volume: 74 Issue: 12 Pages: 2693-2701

    • DOI

      10.1253/circj.CJ-10-0529

    • NAID

      10027424654

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats2010

    • Author(s)
      Unuma K, Shintani-Ishida K, et al
    • Journal Title

      Circulation Journal

      Volume: 74 Issue: 6 Pages: 1087-1095

    • DOI

      10.1253/circj.CJ-09-1019

    • NAID

      10026474454

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brief exposure to carbon monoxide preconditions cardiomyogenic cells against apoptosis in ischemia-reperfusion2010

    • Author(s)
      Kondo-Nakamura M, Shintani-Ishida K, Uemura K, Yoshida K.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 393 Issue: 3 Pages: 449-454

    • DOI

      10.1016/j.bbrc.2010.02.017

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart2010

    • Author(s)
      Unuma K, Shintani-Ishida K, et al
    • Journal Title

      Circulation Journal

      Volume: 74 Pages: 2693-2701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connexin-43 redistribution and gap junction activation during forced restraint protects against sudden arrhythmic death in rats2010

    • Author(s)
      Unuma K, Shintani-Ishida K, et al
    • Journal Title

      Circulation Joural

      Volume: 74 Pages: 1087-1095

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brief exposure to carbon monoxide preconditions cardiomyogenic cells against apoptosis in ischemia-reperfusion2010

    • Author(s)
      Kondo-Nakamura M, Shintani-Ishida K, Uemura K, Yoshida K.
    • Journal Title

      Biochem Biophys Res Commun. 393

      Pages: 449-454

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion2009

    • Author(s)
      Shintani-Ishida K, Unuma K, Yoshida K
    • Journal Title

      Circ J.

      Volume: 73 Pages: 1661-1668

    • URL

      http://dx.doi.org/10.1253/circj.CJ-09-0079

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion2009

    • Author(s)
      Shintani-Ishida K, Unuma K, Yoshida K.
    • Journal Title

      Circulation Journal 73

      Pages: 1661-1668

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-phospholamban antibody introduction enhances opening of mPTP and development of myocardial infarction through uniporter-dependent mitochondrial Ca^<2+> overloading in ischemia-reperfusion2012

    • Author(s)
      新谷香,乾誠,吉田謙一
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 心筋収縮帯と心筋梗塞の関連性2011

    • Author(s)
      新谷香, 黒田亮平, 廣瀬泉, 吉田謙一
    • Organizer
      第95次日本法医学会学術全国集会
    • Place of Presentation
      コラッセふくしま(福島県福島市)
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phospholambanは心筋虚血再灌流時のcontraction bands形成に関与する2010

    • Author(s)
      新谷香,黒田亮平,廣瀬泉,吉田謙一
    • Organizer
      第95次日本法医学会学術全国集会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Phospholambanは心筋虚血再灌流時のcontraction bands形成に関与する2010

    • Author(s)
      新谷香,永井恒志,石井康博,坂幹樹,高橋麻衣子,原田一樹,吉田謙一
    • Organizer
      第94次日本法医学会学術全国集会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 血管がDNA型分析用資料として有用であったバラバラ死体の2症例2009

    • Author(s)
      新谷香, 原田一樹, 中嶋信, 坂幹樹, 伊藤貴子, 高橋麻衣子, 滝沢彩子, 石井康博, 吉田謙一
    • Organizer
      第78回日本法医学会学術関東地方集会
    • Place of Presentation
      東京都千代田区東京歯科大学水道橋校舎
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~forensic/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~forensic

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://Plaza.umin.ac.jp/~forensic/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi