| Budget Amount *help |
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Research Abstract |
Contraction bands(CBs) are formed in early phase of myocardial infarction and have been believed to cause myocardial infarction. In rat model of coronary occlusion, the causality of CB for myocardial infarction was investigated. In ischemia-reperfusion, phospholanban(PLN), a regulatory protein of SR calcium uptake, was dephosphorylated, thereby causing formation of CBs. In vivo injection of anti-PLN antibody enhanced SR calcium uptake and inhibited the CB formation. On the other hand, the antibody induced mPTP opening through mitochondrial calcium overload and enlarged the region of myocardial infarction. These results indicate that mPTP opening, but not CB formation, is pivotal for the development of myocardial infarction.
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