| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
|
|---|
| Research Abstract |
PADI4 gene was identified as one of susceptibility genes for RA using case-control association study. To investigate relationship between PADI4 and RA, we generate Padi4-knockout(KO) mice by the deleting exon 1 and 2.Significant decrement was found in the severity score of the arthritic mice between wild type and Padi4 KO mice in the development of CIA. However, no significant difference was detected in the incidence of the CIA. Padi4 KO mice showed significantly lower levels of anti-CII IgG than that wild type. These data suggested that the function of PADI4 gene is important for RA.
|
