Functional significance of integrin-αvβ3 in the regulation of metastatic potential of malignant melanoma and its therapeutic implication
| Project/Area Number |
21689031
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
JINUSHI Masahisa 北海道大学, 遺伝子病制御研究所, 准教授 (40318085)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 腫瘍免疫 / 免疫療法 / 皮膚腫瘍学 / 腫瘍生物学 / 臨床腫瘍学 / 悪性黒色腫 / インテグリンαvβ3 / MFG-E8 / 抗癌剤耐性 / DNA損傷応答 / 抗腫瘍免疫 / 死細胞貪食 / 樹状細胞 |
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| Research Abstract |
We evaluated the role of integrin-αvβ3 on the regulation of prognosis and therapeutic response of malignant melanoma. The melanoma cells that acquire the resistance to anticancer drugs displayed a significant upregulation of integrin-αvβ3. The integrin-αvβ3 on the chemoresistant melanoma manipulates dendritic cells to induce tolerogenic activities, thereby impairing antitumor immune responses. These findings verified novel molecular machineries whereby tumor resistance to anticancer therapeutics is associated with impairment of host antitumor immunity.
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Report
(3 results)
Research Products
(24 results)
