The Development of Normothermic Perfusion Preservation and"Post-conditioning"Methods in Liver Transplantation

• Project/Area Number: 21689035
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: HATA Koichiro Kyoto University, 医学研究科, 助教 (90523118)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 灌流保存 / 肝移植 / ADAMTS13 / 臓器移植 / 生体肝移植 / 臓器保存

Research Abstract

In this study, we developed a pressure controlled perfusion preservation system, and evaluated the "Post-conditioning" effects in perfusion preservation with Isolated Perfused Rat Liver. It is plausible that normothermic perfusion preservation may preserve/improve the liver function better than cold storage, which is the gold standard preservation method, with protecting hepatic sinusoids.

Research Products

• [Journal Article] Thrombotic microangiopathy-likedisorder after living-donor livertrans plantation (2011)
  • Author(s): Hori T, Kaido T, Hata K, et al(23人中7番目)
  • Journal Title: A single-center experiencein Japan. World J Gastroenterol. 17(14) Pages: 57-1848
  • Peer Reviewed
• [Journal Article] Recurrence of HepatocellularCarcinoma after Living Donor LiverTransplantation (2011)
  • Author(s): Kaido T, Mori A, Hata K, et al(7人中4番目).
  • Journal Title: What is the CurrentOptimal Approach to Prevent Recurrence?World J Surg. 35(6) Pages: 9-1355
  • Peer Reviewed
• [Journal Article] Posttransplant bacteremia inadult living donor liver transplantrecipients. (2010)
  • Author(s): Iida T, Kaido T, Hata K, et al(10人中5番目)
  • Journal Title: Liver Transpl. 16(12) Pages: 85-1379
  • Peer Reviewed
• [Journal Article] Impact of enteral nutrition usinga new immuno-modulating diet after livertransplantation. (2010)
  • Author(s): Kaido T, Mori A, Hata K, et al(8人中4番目)
  • Journal Title: Hepato gastroen terology. 57(104) Pages: 5-1522
  • Peer Reviewed
• [Journal Article] Impact of pretransplantnutritional status in patients undergoingliver transplantation. (2010)
  • Author(s): Kaido T, Mori A, Hata K, et al(9人中6番目)
  • Journal Title: Hepatogastroenterology. 57(104) Pages: 92-1489
  • Peer Reviewed
• [Journal Article] Liver transplantation forcongenital biliary dilatation: asingle-center experience. (2010)
  • Author(s): Hori T, Oike F, Hata K, et al(17人中5番目)
  • Journal Title: Dig Surg. 27(6) Pages: 492-501
  • Peer Reviewed
• [Journal Article] Comprehensive and innovativetechniques for liver transplantation inrats: a surgical guide. (2010)
  • Author(s): Hori T, Nguyen JH, Hata K, et al(31人中18番目)
  • Journal Title: World JGastroenterol. 16(25) Pages: 32-3120
  • Peer Reviewed
• [Journal Article] The rare insertion of b4 withtrifurcated portal vein in live donor. (2010)
  • Author(s): Iida T, Kaido T, Hata K, et al(10人中5番目)
  • Journal Title: Transplantation. 89(9) Pages: 4-1163
  • Peer Reviewed
• [Presentation] ADAMTS13, von Willebrand factorcleaving protease, activity and livergraft preservation; -how to reduce therisk for thrombotic microangiopathy- (2011)
  • Author(s): Hirokazu Tanaka, Koichiro Hata
  • Organizer: the 46th annual European Society forSurgical Research congress
  • Place of Presentation: Aachen, Germany
  • Year and Date: 2011-05-28
• [Presentation] ADAMTS13, von Willebrand factor cleaving protease, activity and liver graft preservation ; how to reduce the risk for Thrombotic microangiopathy? (2011)
  • Author(s): H.Tanaka, K.Hata, et al.
  • Organizer: 46th Congress of the European Society for Surgical Research
  • Place of Presentation: Aachen, Germany