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Aging and Regulation of Bone Metabolism

Research Project

Project/Area Number 21689040
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

MIYAMOTO Takeshi  慶應義塾大学, 医学部・総合医科学研究センター, 特任准教授 (70383768)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords骨 / 軟骨代謝学 / 破骨細胞 / 細胞融合 / 加齢 / 骨代謝 / OC-STAMP
Research Abstract

We identified that transcriptional repressors namely B lymphocyte maturation protein 1(Blimp1) and B cell lymphoma 6(Bcl6) critically regulate osteoclast differentiation and bone homeostasis(J Exp Med 2010). We also identified that osteoclast stimulatory transmembrane protein(OC-STAMP) is required for osteoclast cell-cell fusion(J Bone Miner Res in press).

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (73 results)

All 2012 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (45 results) Book (2 results)

  • [Journal Article] PDGFBB promotes PDGFRα -positive cell migration into artificial bone in vivo2012

    • Author(s)
      Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Kobayashi T, Sato Y, Miyamoto K, Morioka H, Matsumoto M, Chiba K, Toyama Y, Nakagawa T, Miyamoto T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Cartilage Biomarkers for Monitoring Structural Joint Damage in Rheumatoid Arthritis Patients Treated with Anti-TNF Therapy2012

    • Author(s)
      Niki Y, Takeuchi T, Nakayama M, Nagasawa H, Kurasawa T, Yamada H, Toyama Y, Miyamoto T
    • Journal Title

      PLoS One

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012

    • Author(s)
      Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H,Matsumoto M, Chiba K, Toyama Y, Miyamoto T
    • Journal Title

      J Bone Miner Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells2012

    • Author(s)
      Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y and Miyamoto T
    • Journal Title

      J Bone Miner Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012

    • Author(s)
      Fujita K, Iwasaki M, Ochi H, Fukuda T, Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S
    • Journal Title

      Nat Med

      Volume: 18(4) Pages: 589-594

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012

    • Author(s)
      Fujita K, et al
    • Journal Title

      Nat Med

      Volume: 18 Issue: 4 Pages: 589

    • DOI

      10.1038/nm.2659

    • URL

      https://localhost/en/publications/fc70e750-6e59-4813-bc13-47059a99d642

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo behavior of multiple myeloma cells and their niche in immunodeficient mice2012

    • Author(s)
      Iriuchishima H, Kizaki M, et al
    • Journal Title

      PLoS ONE

      Volume: 7(2) Issue: 2 Pages: e30557-e30557

    • DOI

      10.1371/journal.pone.0030557

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells2012

    • Author(s)
      Miyamoto H, et al
    • Journal Title

      J Bone Miner Res

      Volume: (In press) Issue: 6 Pages: 1289-1297

    • DOI

      10.1002/jbmr.1575

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis2012

    • Author(s)
      Hosogane N, et al
    • Journal Title

      J Orthop Res

      Volume: (In press) Issue: 8 Pages: 1249-53

    • DOI

      10.1002/jor.22067

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species2012

    • Author(s)
      Mirza R, et al
    • Journal Title

      J Bone Miner Metab

      Volume: 30 Issue: 2 Pages: 144-153

    • DOI

      10.1007/s00774-011-0303-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T and Miyamoto T
    • Journal Title

      J Exp Med

      Volume: 208(11) Pages: 2175-81

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulators of Osteoclast Differentiation and Cell-Cell Fusion2011

    • Author(s)
      Miyamoto T
    • Journal Title

      Keio J Med

      Volume: 60(4) Pages: 101-105

    • NAID

      10030164455

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-1{beta} and TNF{alpha}-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis2011

    • Author(s)
      Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
    • Journal Title

      Int Immunol

      Volume: 23(11) Pages: 701-12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, et al
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 11 Pages: 2175-2181

    • DOI

      10.1084/jem.20101890

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis2011

    • Author(s)
      Mori T, et al
    • Journal Title

      Int Immunol

      Volume: 23 Issue: 11 Pages: 701-712

    • DOI

      10.1093/intimm/dxr077

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus2011

    • Author(s)
      Cui G, et al
    • Journal Title

      J Orthop Sci

      Volume: 16 Issue: 6 Pages: 785-790

    • DOI

      10.1007/s00776-011-0135-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of osteoporosis in adolescent idiopathic scoliosis : experimental scoliosis in pinealectomized chickens2011

    • Author(s)
      Kono H, et al
    • Journal Title

      J Pineal Res

      Volume: 51 Issue: 4 Pages: 387-393

    • DOI

      10.1111/j.1600-079x.2011.00901.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis2010

    • Author(s)
      Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
    • Journal Title

      J Exp Med

      Volume: vol.207 Pages: 751-762

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Blimp1-Bc16 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010

    • Author(s)
      Miyauchi Y, et al.
    • Journal Title

      J Exp Med.

      Volume: 207 Pages: 751-762

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation2010

    • Author(s)
      Kawasaki T., et al.
    • Journal Title

      Biomaterials 31

      Pages: 1191-1198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts2009

    • Author(s)
      Nagase Y, Iwasawa M, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Hirose J, Nakamura H, Miyamoto T, Bouillet P, Nakamura K, Tanaka S
    • Journal Title

      J Biol Chem

      Volume: 284(52) Pages: 36659-36669

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression2009

    • Author(s)
      Sakai S, Takaishi H, Matsuzaki K, Kaneko H, Furukawa M, Miyauchi Y, Shiraishi A, Saito K, Tanaka A, Taniguchi T, Suda T, Miyamoto T, Toyama Y
    • Journal Title

      J Bone Miner Metab

      Volume: 27(6) Pages: 643-652

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner2009

    • Author(s)
      Miyamoto K, Ninomiya K, Sonoda K, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egarashi K, Suda T, Toyama Y, Miyamoto T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 383 Pages: 373-377

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts2009

    • Author(s)
      Nagase Y., et al.
    • Journal Title

      J Biol Chem 284

      Pages: 36659-36669

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATcl suppression2009

    • Author(s)
      Sakai S., et al.
    • Journal Title

      J Bone Miner Metab 27

      Pages: 643-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner2009

    • Author(s)
      Miyamoto K., et al
    • Journal Title

      Biochem Biophys Res Commun 383

      Pages: 373-377

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] STAT3は関節リウマチ治療の新たな分子標的である2012

    • Author(s)
      森智章, 他
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      ウィル愛知、愛知
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-32αはNFκB/ERKシグナルを介してTNFαを誘導し関節炎の病態に関与する2012

    • Author(s)
      中山政憲, 他
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      ウィル愛知、愛知
    • Related Report
      2011 Annual Research Report
  • [Presentation] OC-STAMP and DC-STAMP are both essential for cell-cell fusion in osteoclasts and foreign body giant cells2012

    • Author(s)
      Hiroya Miyamoto, 他
    • Organizer
      ORS (Orthopedic Research Society) Annual meeting 2012
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] RANKLの下流での破骨細胞制御2012

    • Author(s)
      宮本健史
    • Organizer
      第16回リウマチフォーラム
    • Place of Presentation
      品川プリンスホテル、東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis2011

    • Author(s)
      Miyamoto T, et al
    • Organizer
      1^<st> Bio-Rheumatology International Congress
    • Place of Presentation
      Hilton Bay Tokyo, Chiba
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 炎症と破骨細胞制御機構2011

    • Author(s)
      宮本健史、森智章、吉村昭彦、戸山芳昭
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report
  • [Presentation] OC-STAMPは破骨細胞,異物巨細胞の細胞融合に必須である2011

    • Author(s)
      宮本裕也、森岡秀夫、千葉一裕、戸山芳昭、宮本健史
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report
  • [Presentation] STAT3は関節リウマチ治療の新たな分子標的である2011

    • Author(s)
      森智章、宮本健史、吉村昭彦、戸山芳昭
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report
  • [Presentation] OC-STAMP and DC-STAMP are both essential for cell-cell fusion in osteoclasts and foreign body giant cells2011

    • Author(s)
      Miyamoto H, Morioka H, Chiba K, Toyama Y and Miyamoto T
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research 2011
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] STAT3 is a novel target for treating bone resorption in Rheumatoid arthritis2011

    • Author(s)
      Mori T, Toyama Y, Yoshimura A, Miyamoto T
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research 2011
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] STAT3は関節リウマチ治療の新たな分子標的である2011

    • Author(s)
      森智章、宮本健史、吉村昭彦、戸山芳昭
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 転写抑制因子Blimp1は骨代謝制御の分子標的である2011

    • Author(s)
      宮内芳輝、戸山芳昭、宮本健史
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Aldh2遺伝子変異はアセトアルデヒド及び酸化脂質の蓄積により骨芽細胞の分化抑制をきたす2011

    • Author(s)
      星淡子、呉コウ、戸山芳昭、宮本健史
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] OC-STAMPは破骨細胞、異物巨細胞の細胞融合に必須である2011

    • Author(s)
      宮本裕也、森岡秀夫、千葉一裕、戸山芳昭、宮本健史
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of osteoclast differentiation and cell-cell fusion2011

    • Author(s)
      Miyamoto T
    • Organizer
      Korean Society of Bone Metabolism
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The IRAK4-p38 signal is a differentiation switch for reciprocal formation of osteoclasts and foreign body giant cells2011

    • Author(s)
      Miyamoto H, Morioka H, Chiba K, Toyama Y, Miyamoto T
    • Organizer
      2011 Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Long Beach, California, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-32αのマウスにおける関節炎および敗血症性ショックの誘導効果について2011

    • Author(s)
      中山政憲, 他
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      ベイシア文化ホール、群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] OC-STAMPは破骨細胞,異物巨細胞の細胞融合に必須である2011

    • Author(s)
      宮本裕也, 他
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      ベイシア文化ホール、群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炎症と破骨細胞制御機構2011

    • Author(s)
      宮本健史, 他
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      ベイシア文化ホール、群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腰椎変性側弯症と軟骨代謝マーカーの関連2011

    • Author(s)
      細金直文, 他
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      ベイシア文化ホール、群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Kana Miyamoto, 他
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場、愛知
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutation of ALDH2 genes suppress differentiation to osteoblastic cells by accumulation of acetaldehyde and peroxidated lipid-protein2011

    • Author(s)
      Hiroko Hoshi, 他
    • Organizer
      International osteoporosis foundation (IOF) Regionals, 2^<nd> Asia-Pacific osteoporosis and Bone Meeting
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inflammation and osteoclastogenesis2011

    • Author(s)
      Takeshi Miyamoto
    • Organizer
      8^<th> Meeting of Bone Biology Forum
    • Place of Presentation
      富士教育研修所、静岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] STAT3は関節リウマチ治療の新たな分子標的である2011

    • Author(s)
      森智章, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 転写抑制因子Blimp1は骨代謝制御の分子標的である2011

    • Author(s)
      宮内芳輝, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aldh2遺伝子変異はアセトアルデヒド及び酸化脂質の蓄積により骨芽細胞の分化抑制をきたす2011

    • Author(s)
      星淡子, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] OC-STAMPは破骨細胞、異物巨細胞の細胞融合に必須である2011

    • Author(s)
      宮本裕也, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 転写抑制因子Blimp1-Bc16 axisによる破骨細胞分化および骨恒常性制御2010

    • Author(s)
      宮本健史
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] RANKLによる新たな破骨細胞分化機構2010

    • Author(s)
      宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞融合の新たな展開2010

    • Author(s)
      宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞融合を標的とした破骨細胞制御機構の解明:DC-STAMPによる破骨細胞制御2010

    • Author(s)
      宮本健史
    • Organizer
      第54回日本リウマチ学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 破骨細胞分化を制御する新規因子2010

    • Author(s)
      宮本健史
    • Organizer
      第8回"Japan Conference on Bone & Joint Diseases"研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-23
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 転写抑制因子Blimp1-Bcl6 axisによる破骨細胞分化および骨恒常性制御2010

    • Author(s)
      宮本健史
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] IRAK4-p38シグナルはimplant failureの治療に対する分子標的である2010

    • Author(s)
      宮本裕也、宮本健史、森岡秀夫、千葉一裕、戸山芳昭
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞融合の新たな展開2010

    • Author(s)
      宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] RANKLによる新たな破骨細胞分化機構2010

    • Author(s)
      宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] IRAK4-p38シグナルはimplant failureの治療に対する分子標的である2010

    • Author(s)
      宮本裕也、戸山芳昭、宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Blimp1およびBcl6による破骨細胞分化制御2010

    • Author(s)
      宮内芳輝、千葉一裕、戸山芳昭、宮本健史
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンEは破骨細胞融合を促進し骨量減少を引き起こす2010

    • Author(s)
      藤田浩二、岩崎牧子、古賀貴子、高柳広、龍谷公隆、玉井浩、新井洋由、宮本健史、伊藤裕、四宮謙一、竹田秀
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞融合を標的とした破骨細胞制御機構の解明: DC-STAMPによる破骨細胞制御2010

    • Author(s)
      宮本健史
    • Organizer
      第54回日本リウマチ学会
    • Place of Presentation
      兵庫
    • Related Report
      2011 Final Research Report
  • [Presentation] 転写因子FoxO3aは加齢およびストレス下において造血機能のホメオスターシスを制御する2009

    • Author(s)
      宮本健史, 他(招待講演)
    • Organizer
      第5回麟麟塾
    • Place of Presentation
      東京
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素は内軟骨性骨化における軟骨の肥大化を誘導する2009

    • Author(s)
      宮本健史, 他
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcriptional Regulation of Osteoclastogenesis2009

    • Author(s)
      Miyamoto T.(招待講演)
    • Organizer
      6^<th> Meeting of Bone Biology Forum
    • Place of Presentation
      三島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞分化に魅せられて2009

    • Author(s)
      宮本健史(招待講演)
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 樹状細胞を介した自己免疫寛容制御2009

    • Author(s)
      宮本健史, 他
    • Organizer
      第82回日本整形外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Book] Molecules regulating macrophage fusions. Cell Fusions : Regulation and Control2010

    • Author(s)
      Miyamoto T and Suda T
    • Related Report
      2011 Final Research Report
  • [Book] Vitamin D : Biochemistry, Nutrition and Roles(Vitamin D and Bone). Vitamin D : Biochemistry, Nutrition and Roles,-3rd Quarter2010

    • Author(s)
      Sadaoki Sakai, Yoshiteru Miyauchi, Yoshiaki Toyama, Takeshi Miyamoto
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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