Role of caveolae and caveolinin postconditioning-induced cardiac protection

• Project/Area Number: 21689042
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokushima
• Principal Investigator: TSUTSUMI Yasuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (90523499)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 麻酔学 / 心筋虚血再灌流障害 / 細胞膜マイクロドメイン / カベオラ / 吸入麻酔薬 / 心筋保護作用 / 虚血再灌流障害 / 心筋 / カベオリン / ポストコンディショニング / 虚血再潅流障害

Research Abstract

Caveolae are small, flask-like invaginations of the plasma membrane. Caveolins are structural proteins found in caveolae that have scaffolding properties to allow organization of signaling. The authors tested the hypothesis that cardiac protection induced by postconditioning is caveolae or caveolin dependent.

Research Products

• [Journal Article] Caveolins: targeting pro-survival signaling in the heart and brain. (2012)
  • Author(s): Yasuo Tsutsumi et al
  • Journal Title: Front Physiol Volume: 3 Pages: 393-393
  • Peer Reviewed
• [Journal Article] イソフルランによる心筋保護効果におけるO-linkedβ-N-acetylglucosamineの役割 (2012)
  • Author(s): 広瀬佳代 他
  • Journal Title: 麻酔 Volume: 61
  • Peer Reviewed
• [Journal Article] Differential effects of propofol and isoflurane on glucose utilization and insulin secretion (2011)
  • Author(s): Tanaka K, Tsutsumi Y, Oshita S, et al
  • Journal Title: Life Sciences Volume: Vol.88 Issue: 1-2 Pages: 96-103
  • DOI: 10.1016/j.lfs.2010.10.032
  • Peer Reviewed
• [Journal Article] a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/ PI3K (2011)
  • Author(s): Tsutsumi Y, Tanaka K, Oshita S, et al. Compound K
  • Journal Title: Life Sciences Volume: Vol.88 Issue: 15-16 Pages: 725-729
  • DOI: 10.1016/j.lfs.2011.02.011
  • Peer Reviewed
• [Journal Article] Ingrid R. Niesman, Timo Rieg, Volker Vallon, Paul A. Insel, Hemal H. Patel, and David M. RothCardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. (2011)
  • Author(s): Yousuke T. Horikawa, Mathivadhani Panneerselvam, Yoshitaka Kawaraguchi, Yasuo Tsutsumi, Sameh S. Ali, Ravi C. Balijepalli, Fiona Murray, Brian P
  • Journal Title: J Am Coll Cardiol Volume: 57 Issue: 22 Pages: 2273-2283
  • DOI: 10.1016/j.jacc.2010.12.032
  • Peer Reviewed
• [Journal Article] Role of O-linked beta-N-acetylglucosamine in the cardioprotection induced by isoflurane (2011)
  • Author(s): Hirose K, Tsutsumi Y, Tanaka K, Oshita S, et al.
  • Journal Title: Anesthesiology Volume: Vol.115 Issue: 5 Pages: 955-962
  • DOI: 10.1097/aln.0b013e31822fcede
  • Peer Reviewed
• [Journal Article] Differential effects of propofol and isoflurane on glucose utilization and insulin secretion (2011)
  • Author(s): Tanaka K, et al
  • Journal Title: Life Sciences Volume: 88 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway (2011)
  • Author(s): Tsutsumi Y, et al
  • Journal Title: Life Sciences Volume: 88 Pages: 725-729
  • Peer Reviewed
• [Journal Article] Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling (2011)
  • Author(s): Horikawa Y, et al
  • Journal Title: J Am Coll Cardiol Volume: 57 Pages: 2273-2283
  • Peer Reviewed
• [Journal Article] Brian P. Head, Piyush M. Patel, David M. Roth, and Hemal H. Patel. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. (2010)
  • Author(s): Yasuo Tsutsumi, Yoshitaka Kawaraguchi, Yousuke T. Horikawa, Ingrid R. Niesman, Michael W. Kidd, Blake Chin-Lee
  • Journal Title: Anesthesiology Volume: 112 Issue: 5 Pages: 1136-1145
  • DOI: 10.1097/aln.0b013e3181d3d624
  • Peer Reviewed
• [Journal Article] Opioid-induced preconditioning is dependent on caveolin-3 expression (2010)
  • Author(s): Yasuo Tsutsumi, Yoshitaka Kawaraguchi, Ingrid R. Niesman, Hemal H. Patel, and David M. Roth
  • Journal Title: Anesth Analg Volume: 111 Issue: 5 Pages: 1117-1121
  • DOI: 10.1213/ane.0b013e3181f3351a
  • Peer Reviewed
• [Journal Article] epicatechin-induced cardiac protection is dependent on δ opioid receptor stimulation (2010)
  • Author(s): Mathivadhani Panneerselvam, Yasuo Tsutsumi, Jacqueline A. Bonds, Yousuke T. Horikawa, Michelle Saldana, Nancy D. Dalton, Brian P. Head, Piyush M. Patel, David M. Roth, and Hemal H. Patel
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 299 Issue: 5 Pages: H1604-H1609
  • DOI: 10.1152/ajpheart.00073.2010
  • Peer Reviewed
• [Journal Article] Opioid-induced preconditioning is dependent on caveolin-3 expression. (2010)
  • Author(s): 堤保夫
  • Journal Title: Anesthesia and Analgesia Volume: 111 Pages: 1117-1121
  • Peer Reviewed
• [Journal Article] Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. (2010)
  • Author(s): 堤保夫
  • Journal Title: Anesthesiology Volume: 112 Pages: 1136-1145
  • Peer Reviewed
• [Presentation] アミノ酸の mTOR/p70S6K 経路を介した心筋保護作用の影響 (2012)
  • Author(s): 神邊紀子
  • Organizer: 第59回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2012-08-06
• [Presentation] 心筋保護作用における吸入麻酔薬とゲラニルゲラニルアセトンの相互作用-細胞膜マイクロドメインに及ぼす影響 (2012)
  • Author(s): 堤保夫
  • Organizer: 第59回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2012-08-06
• [Presentation] Protective effects of amino acids on the ischemic myocardium via mTOR/S6 kinase pathway (2012)
  • Author(s): Yasuo Tsutsumi
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: San Diego Convention Center, California, USA
  • Year and Date: 2012-04-23
• [Presentation] Role of calcium-activated potassium channel and cAMP-dependent protein kinase on isoflurane-induced postconditioning. requires caveolin-3 (2011)
  • Author(s): 木下倫子
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: コンベンションセンター(シカゴ)
  • Year and Date: 2011-10-18
• [Presentation] The relation between isoflurane-induced O-linkedβ-N-acetylglucosamine and mitochondrial functio (2011)
  • Author(s): Kayo Hirose
  • Organizer: he American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: Chicago Convention Center, Illinois, USA
  • Year and Date: 2011-10-16
• [Presentation] Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits (2011)
  • Author(s): Katsuya Tanaka
  • Organizer: the American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: Chicago Convention Center, Illinois, USA
  • Year and Date: 2011-10-16
• [Presentation] Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits (2011)
  • Author(s): 田中克哉
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: コンベンションセンター(シカゴ)
  • Year and Date: 2011-10-16
• [Presentation] The relation between isoflurane-induced O-linked β-N-acetylglucosamine and mitochondrial function (2011)
  • Author(s): 廣瀬佳代
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: コンベンションセンター(シカゴ)
  • Year and Date: 2011-10-16
• [Presentation] 、イソフルランのポストコンディショニング効果における Ca2+依存性 K+チャネルと cAMP 依存性プロテインキナーゼの役割 (2011)
  • Author(s): 木下倫子
  • Organizer: 第58回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2011-05-19
• [Presentation] イソフルランによる心筋保護効果における O-Linked β-N-Acetylglucosamine とミトコンドリア機能 (2011)
  • Author(s): 廣瀬佳代
  • Organizer: 第58回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2011-05-19
• [Presentation] イソフルランのポストコンディショニング効果におけるCa2+依存性K+チャネルとcAMP依存性プロテインキナーゼの役割 (2011)
  • Author(s): 木下倫子
  • Organizer: 第58回日本麻酔科学会総会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2011-05-19
• [Presentation] イソフルランによる心筋保護効果におけるO-Linked β-N-Acetylglucosamineとミトコンドリア機能 (2011)
  • Author(s): 廣瀬佳代
  • Organizer: 第58回日本麻酔科学会総会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2011-05-19
• [Presentation] Geranylgeranylacetone induced delayed cardiac preconditioning requires caveolin-3 (2011)
  • Author(s): Yasuo Tsutsumi
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Washington D.C. Convention Center, Washington D.C. USA
  • Year and Date: 2011-04-13
• [Presentation] Geranylgeranylacetone induced delayed cardiac preconditioning requires caveolin-3 (2011)
  • Author(s): 堤保夫
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: コンベンションセンター(Washington D.C.)
  • Year and Date: 2011-04-13
• [Presentation] カベオラおよびその構成タンパクであるカベオリンの心保護作用と麻酔薬 (2010)
  • Author(s): 堤保夫
  • Organizer: 第30回日本臨床麻酔学会総会
  • Place of Presentation: 徳島グランヴィリオホテル(徳島県)
  • Year and Date: 2010-11-04
• [Presentation] The role of O-linked β-N-acetylglucosamine in the cardiac protection induced by isoflurane (2010)
  • Author(s): Kayo Hirose
  • Organizer: the American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: San Diego Convention Center, California, US
  • Year and Date: 2010-10-16
• [Presentation] The role of O-linked β-N-acetylglucosamine in the cardiac protection induced by isoflurane. (2010)
  • Author(s): 廣瀬佳代
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Place of Presentation: サンディエゴコンベンションセンター(カリフォルニア州)
  • Year and Date: 2010-10-16
• [Presentation] オピオイドプレコンディショニングの細胞膜ドメインに及ぼす影響 (2010)
  • Author(s): 堤保夫
  • Organizer: 第56回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2010-08-16
• [Presentation] イソフルランによる心筋保護効果におけるO-Linkedβ-N-Acetylglucosamine の役割 (2010)
  • Author(s): 廣瀬佳代
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡国際会議
  • Year and Date: 2010-06-04
• [Presentation] 吸入麻酔薬による遅延型プレコンディショニングの細胞膜ドメインに及ぼす影響 (2010)
  • Author(s): 堤保夫
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡国際会議場・福岡市
  • Year and Date: 2010-06-04
• [Presentation] 吸入麻酔薬による遅延型プレコンディショニングの細胞膜ドメインに及ぼす影響 (2010)
  • Author(s): 堤保夫
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-06-04
• [Presentation] イソフルランによる心筋保護効果におけるO-Linked β-N-Acetylglucosamineの役割 (2010)
  • Author(s): 廣瀬佳代
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-06-04
• [Presentation] Role of mTOR/p70S6K in amino acid induced cardiac protection (2010)
  • Author(s): Erika Katayama
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Anaheim, Convention Center, California, USA.
  • Year and Date: 2010-04-27
• [Presentation] Inhibition of glycogen synthase kinase-3β is involved in isoflurane-induced delayed cardiac protection (2010)
  • Author(s): Yoshitaka Kawaraguchi
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Anaheim Convention Center, California, USA.
  • Year and Date: 2010-04-26
• [Presentation] Inhibition of glycogen synthase kinase-3β is involved in isoflurane-induced delayed cardiac protection. (2010)
  • Author(s): 瓦口至孝
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: アナハイム・コンベンションセンター(カリフォルニア州)
  • Year and Date: 2010-04-26
• [Presentation] produces cardiac protection by activating Akt phosphorylation. (2010)
  • Author(s): Rie Tsutsumi, Compound K
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Anaheim Convention Center, California, US
  • Year and Date: 2010-04-25
• [Presentation] Role of O-linked β-N-acetylglucosamine in isoflurane induced cardiac protection. (2010)
  • Author(s): Yasuo Tsutsumi
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Anaheim Convention Center, California, USA.
  • Year and Date: 2010-04-25
• [Presentation] Role of O-linked β-N-acetylglucosamine in isoflurane induced cardiac protection. (2010)
  • Author(s): 堤保夫
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: アナハイム・コンベンションセンター(カリフォルニア州)
  • Year and Date: 2010-04-25
• [Presentation] Role of Caveolin-3 and Caveolae in Isoflurane-Induced Delayed Cardiac Protection. (2009)
  • Author(s): 瓦口至孝
  • Organizer: umerican Society of Anesthesiologists mnual Meeting
  • Place of Presentation: ニューオリンズ・コンベンションセンター(ルイジアナ)
  • Year and Date: 2009-10-18
• [Presentation] オピオイドプレコンディショニングの細胞膜ドメインに及ぼす影響 (2009)
  • Author(s): 堤保夫
  • Organizer: 第56回日本麻酔科学会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2009-08-16
• [Presentation] Opioid-induced preconditioning is dependent on caveolin-3 expression. (2009)
  • Author(s): 堤保夫
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: ニューオリンズ・コンベンションセンター(ルイジアナ)
  • Year and Date: 2009-04-21
• [Presentation] Cardiac myocyte-specific caveolin-3 overexpression modulates ANP produ ction and attenuates cardiac hypertrophy in vivo. (2009)
  • Author(s): 堀川洋介
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: ニューオリンズ・コンベンションセンター(ルイジアナ)
  • Year and Date: 2009-04-19
• [Presentation] Protective effects of amino acids on the ischemic myocardium via mTOR/S6 kinase pathway.
  • Author(s): Yasuo Tsutsumi et al
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: San Diego Convention Center（USA）
• [Presentation] 敗血症マウスにおける分岐鎖アミノ酸投与が筋タンパク合成に及ぼす影響
  • Author(s): 堤保夫 他
  • Organizer: 第59回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] アミノ酸のmTOR/p70S6K経路を介した心筋保護作用の影響
  • Author(s): 神邊紀子 他
  • Organizer: 第59回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 心筋保護作用における吸入麻酔薬とゲラニルゲラニルアセトンの相互作用―細胞膜マイクロドメインに及ぼす影響―
  • Author(s): 堤保夫 他
  • Organizer: 第59回日本麻酔科学会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Glucagon-like peptide-1 induced cardiac protection is dependent on caveolin-3 expression
  • Author(s): Eisuke Hamaguchi et al
  • Organizer: Experimental Biology Annual Meeting
  • Place of Presentation: Boston Convention Center（USA）
• [Presentation] 吸入麻酔薬およびGLP-1の細胞膜マイクロドメインを介した心筋保護作用
  • Author(s): 濵口英佑 他
  • Organizer: 第60回日本麻酔科学会
  • Place of Presentation: ロイトン札幌（北海道）
• [Book] 大下修造「徹底ガイド 心臓麻酔 Q&A-心臓麻酔における臓器保護-心臓手術中の心筋保護」麻酔科学レクチャー (2009)
  • Author(s): 田中克哉、堤保夫、
  • Publisher: 総合医学社
• [Book] 徹底ガイド 心臓麻酔 Q&A (2009)
  • Author(s): 田中克哉、堤保夫、大下修造
  • Publisher: 総合医学社
• [Remarks]
  • URL: http://www.tokushima-u.ac.jp/med/culture/masui_totsu/ikyoku/