Search for immunopotentiating adjuvants in cancer vaccine therapy for gynecologic malignancies

• Project/Area Number: 21689044
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Waseda University (2010); Tokyo Women's Medical University (2009)
• Principal Investigator: ONO Satoshi Waseda University, 先端科学・健康医療融合研究機構, 研究員 (90345629)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000); Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
• Keywords: 癌 / WT1 / ワクチン療法 / マクロファージ / トランスレーショナルリサーチ / 樹状細胞

Research Abstract

The purpose of this study was to explore a novel adjuvant aimed at re-activation of macrophage cells, which may improve the therapeutic efficacy of cancer vaccines. We conducted clinical trial of WT1 peptide vaccine with CpG or GM-CSF combination therapy, and examined its safety and efficacy. As a result, GM-CSF and CpG was found to be safely combined immunopotentiating adjuvants.

Research Products

• [Journal Article] Frequencies of myeloid dendritic cells can predicts the efficacy of Wilms' Tumor 1 (WT1) peptide vaccination. (2011)
  • Author(s): Ohno S, Takano F, Ohta Y, Kyo S, Myojo S, Dohi S, Sugiyama H, Ohta H, Inoue M
  • Journal Title: Anticancer Res. (印刷中)
  • Peer Reviewed
• [Journal Article] WT1 peptide vaccine stabilized intractable ovarian cancer patient over one year : a case report. (2011)
  • Author(s): Dohi S, Ohno S, Ohno Y, Takakura M, Kyo S, Soma G, Sugiyama H, Inoue M
  • Journal Title: Anticancer Res. (印刷中)
  • Peer Reviewed
• [Journal Article] Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. (2011)
  • Author(s): Ohno S, Sumiyoshi Y, Hashine K, Shirato A, Kyo S, Inoue M
  • Journal Title: Evid Based Complement Alternat Med. (印刷中)
  • Peer Reviewed
• [Journal Article] WT1 expression correlates with angiogenesis in endometrial cancer tissue. (2010)
  • Author(s): Dohi S, Ohno S, Ohno Y, Kyo S, Soma G, Sugiyama H, Inoue M
  • Journal Title: Anticancer Res. Vol.30, No.8 Pages: 3187-3192
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer. (2010)
  • Author(s): Nakamura M, Kyo S, Zhang B, Zhang X, Mizumoto Y, Takakura M, Maida Y, Mori N, Hashimoto M, Ohno S, Inoue M
  • Journal Title: Hum Pathol. Vol.41, No.11 Pages: 1516-1529
  • Peer Reviewed
• [Journal Article] Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer. (2010)
  • Author(s): Mori N, Kyo S, Nakamura M, Hashimoto M, Maida Y, Mizumoto Y, Takakura M, Ohno S, Kiyono T, Inoue M
  • Journal Title: Br J Cancer. Vol.103, No.6 Pages: 889-898
  • Peer Reviewed
• [Journal Article] An indication for correlation between the serum ADA level and gastric cancer risk. (2010)
  • Author(s): Ri G, Ohno S, Furutani M, Furutani Y, Tsukahara T, Hagita N, Haruyama H, Nakamura S, Yamamoto T, Matsuoka R
  • Journal Title: Anticancer Res. Vol.30, No.6 Pages: 2347-2349
  • Peer Reviewed
• [Journal Article] Correlation between WT1 expression and cell proliferation in endometrial cancer. (2010)
  • Author(s): Dohi S, Ohno S, Ohno Y, Soma G, Kyo S, Inoue M
  • Journal Title: Anticancer Res. Vol.29, No.11 Pages: 4887-4892
  • Peer Reviewed
• [Journal Article] 統合医療とは (2010)
  • Author(s): 新田新一、辻本好子、中村一徳、小俣浩、大野智
  • Journal Title: 全日本鍼灸学会雑誌 第61巻第1号 Pages: 17-36
  • NAID: 10031188719
• [Journal Article] 補完代替医療とリスクマネジメント (2010)
  • Author(s): 大野智
  • Journal Title: 助産師 第64巻第3号 Pages: 8-13
• [Journal Article] がんの医療現場における機能性食品の現状と課題 (2010)
  • Author(s): 大野智
  • Journal Title: ケミカルエンジニアリング 第55巻第4号 Pages: 277-284
• [Journal Article] がん患者のサバイバーシップ;がんの補完代替療法 (2010)
  • Author(s): 大野智
  • Journal Title: 腫瘍内科 第5巻第2号 Pages: 156-164
• [Journal Article] 伝統医療・補完医療・代替医療 (2010)
  • Author(s): 大野智
  • Journal Title: 理学療法ジャーナル 第44巻第7号 Pages: 590-590
• [Journal Article] WT1 expression correlates with angiogenesis in endometrial cancer tissue (2010)
  • Author(s): Dohi S, Ohno S, 他
  • Journal Title: Anticancer Res Volume: 30 Pages: 3187-3192
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer (2010)
  • Author(s): Nakamura M, Ohno S, 他
  • Journal Title: Hum Pathol Volume: 41 Pages: 1516-1529
  • Peer Reviewed
• [Journal Article] Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer (2010)
  • Author(s): Mori N, Ohno, S, 他
  • Journal Title: Br J Cancer Volume: 103 Pages: 889-898
  • Peer Reviewed
• [Journal Article] An indication for correlation between the serum ADA level and gastric cancer risk (2010)
  • Author(s): Ri G, Ohno S, 他
  • Journal Title: Anticancer Res Volume: 30 Pages: 2347-2349
  • Peer Reviewed
• [Journal Article] Wilms' tumor 1 (WT1) peptide immunotherapy for gynecological malignancy. (2009)
  • Author(s): Ohno S, Kyo S, Myojo S, Dohi S, Ishizaki J, Miyamoto K, Morita S, Sakamoto J, Enomoto T, Kimura T, Oka Y, Tsuboi A, Sugiyama H, Inoue M
  • Journal Title: Anticancer Res. Vol.29, No.11 Pages: 4779-4784
  • Peer Reviewed
• [Journal Article] Serum levels of CA15-3, KL-6 and BCA225 are positively correlated with each other in the general population. (2009)
  • Author(s): Ri G, Ohno S, Yamamoto T, Ito E, Furutani M, Furutani Y, Umeda Y, Tsukahara T, Hagita N, Matsuoka R
  • Journal Title: Anticancer Res. Vol.29, No.10 Pages: 4239-4242
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of WT1 protein in endometrial cancer. (2009)
  • Author(s): Ohno S, Dohi S, Ohno Y, Kyo S, Sugiyama H, Suzuki N, Inoue M
  • Journal Title: Anticancer Res. Vol.29, No.5 Pages: 1691-1695
  • Peer Reviewed
• [Journal Article] High-Dose Vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. (2009)
  • Author(s): Ohno S, Ohno Y, Suzuki N, Soma G, Inoue M
  • Journal Title: Anticancer Res. Vol.29, No.3 Pages: 809-815
  • Peer Reviewed
• [Journal Article] 悪性腫瘍における補完代替医療の実際 (2009)
  • Author(s): 大野智
  • Journal Title: 日本産科婦人科学会雑誌 第61巻第9号 Pages: 362-367
  • NAID: 110007360072
• [Journal Article] Immunohistochemical detection of WT1 protein in endometrial cancer. (2009)
  • Author(s): Ohno S, et al.
  • Journal Title: Anticancer Research Vol.29 Pages: 1691-1695
  • Peer Reviewed
• [Journal Article] Wilms' tumor 1(WT1) peptide immunotherapy for gynecological malignancy (2009)
  • Author(s): Ohno S, et al.
  • Journal Title: Anticancer Research Vol.29 Pages: 4779-4784
  • Peer Reviewed
• [Journal Article] Correlation between WT1 expression and cell proliferation inendometrial cancer (2009)
  • Author(s): Dohi S, et al.
  • Journal Title: Anticancer Research Vol.29 Pages: 4887-4892
  • Peer Reviewed
• [Journal Article] 補完代替医療の現状と展望
  • Author(s): 大野智
  • Journal Title: 食品加工技術 (印刷中)
  • NAID: 40019040427
• [Journal Article] 婦人科悪性腫瘍における代替医療の実際
  • Author(s): 大野智
  • Journal Title: 婦人科治療 第100巻第3号 Pages: 340-346
• [Presentation] 癌ペプチドワクチン療法施行患者における末梢血中樹状細胞(Dendritic Cell)の意義 (2010)
  • Author(s): 大野智、土肥聡、京哲、高野文英、太田富久、井上正樹
  • Organizer: 第14回バイオ治療法研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-12-11
• [Presentation] 抗癌剤治療抵抗性卵巣癌患者に対してWT1ペプチドワクチン療法よる長期間病状安定が得られた1症例 (2010)
  • Author(s): 土肥聡、大野智、大野由美子、杣源一郎、京哲、杉山治夫、井上正樹
  • Organizer: 第14回バイオ治療法研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-12-11
• [Presentation] 婦人科悪性腫瘍に対するWT1ペプチドがん免疫療法 (2010)
  • Author(s): 大野智、土肥聡、明星須晴、京哲、井上正樹
  • Organizer: 第48回日本癌治療学会学術集会パネルディスカッション
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] 婦人科悪性腫瘍に対するWT1ペプチドがん免疫療法 (2010)
  • Author(s): 大野智
  • Organizer: 第48回日本癌治療学会学術集会(パネルディスカッション)
  • Place of Presentation: 国立京都国際会館(京都府)(招待講演)
  • Year and Date: 2010-10-29
• [Presentation] 婦人科悪性腫瘍における補完医療の取り組み (2010)
  • Author(s): 大野智
  • Organizer: 第58回日本産婦人科学会北日本連合地方部会クリニカルフロントライン
  • Place of Presentation: 金沢
  • Year and Date: 2010-09-18
• [Presentation] 婦人科悪性腫瘍における補完医療の取り組み (2010)
  • Author(s): 大野智
  • Organizer: 第58回日本産婦人科学会北日本連合地方部会総会
  • Place of Presentation: 金沢市文化ホール(石川県)(招待講演)
  • Year and Date: 2010-09-18
• [Presentation] 子宮体癌におけるVEGFを介したWT1による血管新生の可能性 (2010)
  • Author(s): 土肥聡、大野智、大野由美子、杣源一郎、京哲、杉山治夫、井上正樹
  • Organizer: 第11回WT1免疫療法研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-02-13
• [Presentation] マクロファージ系細胞の制御を機軸とした癌の治療戦略 (2009)
  • Author(s): 大野智
  • Organizer: 第13回バイオ治療法研究会ワークショップ
  • Place of Presentation: 高松
  • Year and Date: 2009-12-05
• [Presentation] 子宮体癌におけるWT1蛋白発現と血管新生の関連性 (2009)
  • Author(s): 土肥聡、大野智、大野由美子、杣源一郎、京哲、杉山治夫、井上正樹
  • Organizer: 第13回バイオ治療法研究会
  • Place of Presentation: 高松
  • Year and Date: 2009-12-05
• [Presentation] Wilms'tumor 1 (WT1) peptide immunotherapy for gynecological malignancy (2009)
  • Author(s): 大野智、明星須晴、土肥聡、京哲、石崎純子、宮本謙一、杉山治夫、井上正樹
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Correlation between WT1 expression and cell proliferation in endometrial cancer (2009)
  • Author(s): 土肥聡、大野智、大野由美子、杣源一郎、京哲、杉山治夫、井上正樹
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 婦人科悪性腫瘍におけるWT1ペプチドワクチン療法 (2009)
  • Author(s): 大野智, 他
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-02
• [Presentation] WT1 expression as prognostic factor in endometrial cancer (2009)
  • Author(s): Dohi S, Ohno S, Ohno Y, Kyo S, Sugiyama H, Inoue M
  • Organizer: The 4th International Conference on WT1 in Human Neoplasia
  • Place of Presentation: Kyoto
  • Year and Date: 2009-09-10
• [Presentation] 悪性腫瘍における代替医療の実際 (2009)
  • Author(s): 大野智
  • Organizer: 第61回日本産科婦人科学会学術講演会クリニカルカンファレンス
  • Place of Presentation: 京都
  • Year and Date: 2009-04-04
• [Book] がんの統合医療(分担項目:第26章がんの初期治療としての代替療法、メディカル・サイエンス・インターナショナル)(原著:Donald I.Abrams, Andrew T.Weil(編集): Integrative Oncology, Oxford University Press (2009)) (2010)
  • Author(s): 伊藤壽記、上島悦子(監訳)