Search for immunopotentiating adjuvants in cancer vaccine therapy for gynecologic malignancies
Project/Area Number |
21689044
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Waseda University (2010) Tokyo Women's Medical University (2009) |
Principal Investigator |
ONO Satoshi Waseda University, 先端科学・健康医療融合研究機構, 研究員 (90345629)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
|
Keywords | 癌 / WT1 / ワクチン療法 / マクロファージ / トランスレーショナルリサーチ / 樹状細胞 |
Research Abstract |
The purpose of this study was to explore a novel adjuvant aimed at re-activation of macrophage cells, which may improve the therapeutic efficacy of cancer vaccines. We conducted clinical trial of WT1 peptide vaccine with CpG or GM-CSF combination therapy, and examined its safety and efficacy. As a result, GM-CSF and CpG was found to be safely combined immunopotentiating adjuvants.
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer.2010
Author(s)
Nakamura M, Kyo S, Zhang B, Zhang X, Mizumoto Y, Takakura M, Maida Y, Mori N, Hashimoto M, Ohno S, Inoue M
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Journal Title
Hum Pathol. Vol.41, No.11
Pages: 1516-1529
Related Report
Peer Reviewed
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[Journal Article] Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer.2010
Author(s)
Mori N, Kyo S, Nakamura M, Hashimoto M, Maida Y, Mizumoto Y, Takakura M, Ohno S, Kiyono T, Inoue M
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Journal Title
Br J Cancer. Vol.103, No.6
Pages: 889-898
Related Report
Peer Reviewed
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[Journal Article] An indication for correlation between the serum ADA level and gastric cancer risk.2010
Author(s)
Ri G, Ohno S, Furutani M, Furutani Y, Tsukahara T, Hagita N, Haruyama H, Nakamura S, Yamamoto T, Matsuoka R
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Journal Title
Anticancer Res. Vol.30, No.6
Pages: 2347-2349
Related Report
Peer Reviewed
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[Journal Article] Wilms' tumor 1 (WT1) peptide immunotherapy for gynecological malignancy.2009
Author(s)
Ohno S, Kyo S, Myojo S, Dohi S, Ishizaki J, Miyamoto K, Morita S, Sakamoto J, Enomoto T, Kimura T, Oka Y, Tsuboi A, Sugiyama H, Inoue M
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Journal Title
Anticancer Res. Vol.29, No.11
Pages: 4779-4784
Related Report
Peer Reviewed
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[Journal Article] Serum levels of CA15-3, KL-6 and BCA225 are positively correlated with each other in the general population.2009
Author(s)
Ri G, Ohno S, Yamamoto T, Ito E, Furutani M, Furutani Y, Umeda Y, Tsukahara T, Hagita N, Matsuoka R
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Journal Title
Anticancer Res. Vol.29, No.10
Pages: 4239-4242
Related Report
Peer Reviewed
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