| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Research Abstract |
We investigated the influences of cyclic stretch on the differentiation capacity of adipose-derived adult stem cells, however, no positive data are obtained for the clinical use. We consider the possibilities that mechanical stress influences mesenchymal tissues through adjacent tissue such as epidermis, therefore we investigated the influences of cyclic stretch on keratinocyte, focusing on expression levels of cytokines which are known to work on mesenchymal tissue with paracrine fashion. As a result, we found keratinocyte-derived endothelin-1 was upregulated with mechanical stretch (Kurita et al. BBRC 2011).
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