Budget Amount *help |
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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Research Abstract |
Focal adhesion kinase(FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK overexpression is frequently found in invasive and metastatic cancers, but its role in osteolytic metastasis is not well understood. In this study, we have analyzed anti-tumor effects of the FAK against bone metastasis in cancer, we found that FAK was critically involved in osteolytic metastasis and activated in tumors, pre-osteoclasts, and mature osteoclasts. These results suggest that FAK can be effective target for the treatment of cancer induced bone metastasis.
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