Biological and psychological study on impulsive behavior

• Project/Area Number: 21700290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cognitive science
• Research Institution: Kyoto University (2010); Hiroshima University (2009)
• Principal Investigator: NOMURA Michio Kyoto University, 大学院・教育学研究科, 准教授 (60399011)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 衝動性 / 運動制御 / 感情制御 / ドーパミン神経系遺伝子多型 / 前頭前野腹外側部 / COMT / 遺伝子多型 / セロトニン / ドパミン / 報酬 / 罰

Research Abstract

Brain neuro-imaging studies with concurrent neuro-pharmacological measurement of the effect of gene polymorphisms appear to be useful in clarifying the relationships between personality traits and information processing within distinct brain regions. Catechol-O-methyltransferase (COMT) is involved in functional modulation dopamine neurons and is thus likely to influence frontal-executive functioning. Using functional magnetic resonance imaging (f MRI), we examined whether and how this COMT Val 158 Met gene polymorphism modulates impulsivity-related brain activation by evaluating a Go/No-go task. We found that the COMT Val 158 Met genotypes influence the human prefrontal brain activation and the genotype underlies impulsivity-related motor control appropriate to the affective structure of an environment through reward and penalty information.

Research Products

• [Journal Article] Theeffects of reward and punishment onresponse inhibition in non-clinicalpsychopathy (2011)
  • Author(s): Masui, K., Nomura, M.
  • Journal Title: Personality andIndividual Differences 50 Pages: 269-73
• [Journal Article] 衝動性の基盤となるヒト前頭前野に及ぼすCOMT Val 158 Met 遺伝子多型の影響 (2011)
  • Author(s): 野村理朗・近藤洋史・柏野牧夫
  • Journal Title: Japanese journal ofpsychopharmacology 31 Pages: 85-86
  • NAID: 10029094162
• [Journal Article] The effects of reward and Punishment on response inhibition in non-clinical psychopathy (2011)
  • Author(s): Masui, K., Nomura, M.
  • Journal Title: Personality and Individual Differences Volume: 50 Pages: 69-73
  • NAID: 120002753740
  • Peer Reviewed
• [Journal Article] Impulsivity-related human prefrontal brain activation during Go/No-go task is moderated by COMT Val 158 Met gene polymorphism : a fMRI study (2011)
  • Author(s): Nomura, M., Kondo, M.H., Kashino, M.
  • Journal Title: Japanese journal of psychopharmacology Volume: (印刷中)
• [Journal Article] 衝動性の基盤となる構成概念,脳,遺伝子多型について-Stop Signal Paradaigm の観点より (2010)
  • Author(s): 増井啓太・野村理朗
  • Journal Title: 感情心理学研究 18 Pages: 15-24
• [Journal Article] 衝動性の基盤となる構成概念,脳,遺伝子多型について-Stop Signal Paradaigmの観点より- (2010)
  • Author(s): 増井啓太・野村理朗
  • Journal Title: 感情心理学研究 Volume: 18 Pages: 15-24
  • Peer Reviewed
• [Journal Article] 衝動性の基盤となる構成概念、脳、遺伝子多型について-Stop Signal Paradigmの観点より- (2010)
  • Author(s): 増井啓太、野村理朗
  • Journal Title: 感情心理学研究 (掲載決定)
  • Peer Reviewed
• [Journal Article] Psychological andbiological basis of impulsive behavior. (2009)
  • Author(s): Nomura, M.
  • Journal Title: Nova Science Publishers Pages: 207-215
• [Journal Article] Ventrolateral prefrontal cortex activityduring reward-punishment Go/Nogo task : Anear-infrared spectroscopy study. (2009)
  • Author(s): Masui, K., Kashino, M., Nomura, M.
  • Journal Title: Psychologia 52 Pages: 137-146
• [Journal Article] Psychological and biological basis of impulsive behavior (2009)
  • Author(s): Michio Nomura
  • Journal Title: Nova Science Publishers Pages: 207-215
  • Peer Reviewed
• [Journal Article] Ventrolateral prefrontal cortex activity during reward-punishment Go/Nogo task : A near-infrared spectroscopy study (2009)
  • Author(s): Masui Keita, Kashino Makio, Michio Nomura
  • Journal Title: Psychologia 52 Pages: 122-131
  • NAID: 130000137908
  • Peer Reviewed
• [Presentation] 生体内外の環境がヒト情動・認知の制御機能に及ぼす影響(教育講演) (2010)
  • Author(s): 野村理朗
  • Organizer: ブレインサイエンス研究会
  • Place of Presentation: 九州市学術研究都市
  • Year and Date: 2010-12-11
• [Presentation] 生体内外の環境がヒト情動・認知の制御機能に及ぼす影響 (2010)
  • Author(s): 野村理朗
  • Organizer: ブレインサイエンス研究会
  • Place of Presentation: 北九州市学術研究都市(教育講演 招待講演)
  • Year and Date: 2010-12-11
• [Presentation] Therelationship between response disinhibitionand rVLPFC deactivation in psychopathicparticipants : A near-infrared spectroscopystudy. (2010)
  • Author(s): Masui, K., Nomura, M.
  • Organizer: 50th Annual Meeting of Society forPsychophysiological Research.
  • Place of Presentation: Portland, USA.
  • Year and Date: 2010-09-29
• [Presentation] The relationship between response disinhibition and rVLPFC deactivation in Psychopathic participants (2010)
  • Author(s): Masui, K., Nomura, M.
  • Organizer: 50th Annual Meeting of Society for Psychophy siological Research
  • Place of Presentation: Portland, USA
  • Year and Date: 2010-09-29
• [Presentation] 衝動性に及ぼすサイコパシー特性及び報酬・罰感受性の影響-NIRSを用いた検討- (2010)
  • Author(s): 増井啓太・野村理朗
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-20
• [Presentation] Impulsivity-related human prefrontal brain activation during Go/No-go task is moderated by COMT Val 158 Met polymorphism : a fMRI study (2010)
  • Author(s): Nomura, M., Kondo, M.H., Kashino, M.
  • Organizer: The International College of Neuropsychophar macology
  • Place of Presentation: Honkong, China
  • Year and Date: 2010-06-07
• [Presentation] Go/Nogoポテンシャル (2009)
  • Author(s): 野村理朗
  • Organizer: 日本臨床神経生理学会大会 シンポジウム
  • Place of Presentation: 小倉市
  • Year and Date: 2009-11-19
• [Presentation] 衝動性に及ぼす報酬・罰により生じる葛藤の影響-NIRSを用いた検討- (2009)
  • Author(s): 増井啓太・野村理朗
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 立命館大学
  • Year and Date: 2009-09-27
• [Presentation] 他者との関係性及び取得される視点が感情推測プロセスに及ぼす影響-NIRSを用いた検討- (2009)
  • Author(s): 野村祐子・小河妙子・柏野牧夫・野村理朗
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 立命館大学
  • Year and Date: 2009-09-27
• [Presentation] 刺激希求性が反応抑制課題中のリスクテイキングに及ぼす影響 (2009)
  • Author(s): 宗像あゆみ・野村理朗
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 立命館大学
  • Year and Date: 2009-09-27
• [Presentation] 衝動性に及ぼすサイコパシー特性及び報酬・罰感受性の影響-NIRSを用いた検討 (2009)
  • Author(s): 増井啓太・野村理朗
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-09-20
• [Presentation] COMT遺伝子多型は共感性の個人差を生むのか?-NIRSを用いた認知神経科学的検討 (2009)
  • Author(s): 日道俊之・野村理朗
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-09-20
• [Presentation] Impulsivity-related human prefrontal brainactivation during Go/No-go task is moderated by COMT Val 158 Met polymorphism : a fMRI study. (2009)
  • Author(s): Nomura, M., Kondo, M.H., Kashino, M.
  • Organizer: TheInternational College of Neuropsychopharmacology
  • Place of Presentation: Honkong, China
  • Year and Date: 2009-06-07
• [Presentation] COMT Val 158 Met polymorphism modulatesimpulsivity-related human behavior. (2009)
  • Author(s): Nomura, M., Kondo, M.H., Kashino, M.
  • Organizer: TheInternational College of Neuropsychopharmacology,1st IBRO MIDDLE EAST NEUROSCIENCE CONFERENCE
  • Place of Presentation: Al Ain, UAE
  • Year and Date: 2009-02-09
• [Book] 社会的認知の神経基盤「個人の中の社会(1)日本社会心理学会50周年企画」(浦光博・北村英哉(編)) (2010)
  • Author(s): 野村理朗
  • Publisher: 誠心書房
• [Book] 社会的認知の神経基盤浦光博・北村英哉(編)「個人の中の社会(1)」 (2010)
  • Author(s): 野村理朗
  • Publisher: 誠心書房
• [Book] 社会的認知の神経基盤 「個人の中の社会(1)」 (2010)
  • Author(s): 野村理朗
  • Publisher: 誠心書房(掲載決定)
• [Book] 細胞間シグナリングと薬物治療標準医療薬学「薬理学」(辻本豪三・小池隆夫(編)) (2009)
  • Author(s): 野村理朗・野村靖幸
  • Publisher: 医学書院
• [Book] 人格の生物学的基礎「社会心理学事典」 (2009)
  • Author(s): 野村理朗
  • Publisher: 丸善出版社
• [Remarks] ホームページ
  • URL: http://www.educ.kyoto-u.ac.jp/cogpsy/
• [Remarks] 学会賞受賞:Nomura M. 2010 JSNP Excellent Presentation Award for CINP 2010