Development of statistical methods for brain research

• Project/Area Number: 21700312
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Statistical science
• Research Institution: Kurume University
• Principal Investigator: KAWAGUCHI Atsushi 久留米大学, バイオ統計センター, 講師 (60389319)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳 / 神経 / 画像解析 / 国際情報交換 / 高次元データ / バイオ統計学 / 統計数学 / ノンパラメトリック / 脳・神経 / アメリカ / 多変量解析

Research Abstract

Statistical methods applied to brain research were proposed based on the nonparametric method which required no assumption on the data structure and enable us to apply to several data analysis. A simulation study showed more significant advantage for the proposed method comparing with existing methods. We ve also effectively learned about Parkinson's disease and malignant glioma from our statistical analysis

Research Products

• [Journal Article] Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients (2012)
  • Author(s): Kawaguchi, A., Yajima N., Komohara Y., Aoki H., Tsuchiya N., Homma J., Sano M., Natsumeda M., Uzuka T., Saitoh A., Takahashi H., Sakai Y., Takahashi H., Fujii Y., Kakuma T. and Yamanaka R.
  • Journal Title: International Journal of Oncology Volume: Volume 40 Number 3 Pages: 721-730
  • Peer Reviewed
• [Journal Article] Identification and Validation of a Gene Expression Signature That Predicts Outcome in Malignant Glioma Patients (2012)
  • Author(s): Kawaguchi A, Yamanaka R, 他
  • Journal Title: Int J Oncol Volume: 40(3) Pages: 721-30
  • DOI: 10.3892/ijo.2011.1240
  • Peer Reviewed
• [Journal Article] Logspline independent component analysis (2011)
  • Author(s): Kawaguchi, A. and Truong, K. Y.
  • Journal Title: Bulletin of Informatics and Cybernetics Volume: 43 Pages: 83-94
  • NAID: 120005397802
  • Peer Reviewed
• [Journal Article] Stratified Multivariate Mann-Whitney Estimators for the Comparison of Two Treatments with Randomization Based Covariance Adjustment (2011)
  • Author(s): Kawaguchi, A., Koch, G. G., Wang, X
  • Journal Title: Statistics in Biopharmaceutical Research Volume: Vol.3, No.2 Pages: 217-231
  • Peer Reviewed
• [Journal Article] Differential involvement of striato-and cerebello-thalamo-cortical pathways in tremor-and akinetic/rigid-predominant Parkinson's disease (2011)
  • Author(s): Lewis, M. M., Du G., Sen S., Kawaguchi, A., Truong, Y. Lee, S. Mailman, R. B. Huang, X.
  • Journal Title: Neuroscience Volume: Volume 177, Issue 17 Pages: 230-239
  • Peer Reviewed
• [Journal Article] Stratified Multivariate Mann-Whitney Estimators for the Comparison of Two Treatments with Randomization Based Covariance Adjustment (2011)
  • Author(s): Kawaguchi A.
  • Journal Title: Statistics in Biopharmaceutical Research Volume: 3 Issue: 2 Pages: 217-231
  • DOI: 10.1198/sbr.2010.10007
  • Peer Reviewed
• [Journal Article] Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease (2011)
  • Author(s): Lewis, M.M.
  • Journal Title: Neuroscience Volume: 177 Pages: 230-239
  • Peer Reviewed
• [Journal Article] Multivariate Mann-Whitney Estimators for the Comparison of Two Treatments in a Three Period Crossover Study with Randomly Missing Data (2010)
  • Author(s): Kawaguchi, A. and Koch, G. G.
  • Journal Title: Journal of Biopharmaceutical Statistics Volume: Volume 20 Issue 4 Pages: 720-744
  • Peer Reviewed
• [Journal Article] Statistical Inference for Independent Component Analysis Based on Polynomial Spline Model (2010)
  • Author(s): Kawaguchi, A.
  • Journal Title: Lecture Notes in Engineering and Computer Science Pages: 478-480
  • Peer Reviewed
• [Journal Article] Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease (2010)
  • Author(s): Sen S., Kawaguchi A., Truong K. Y., Lewis M. M., and Huang X.
  • Journal Title: Neuroscience Volume: Volume 166, Issue 2 Pages: 712-719
  • Peer Reviewed
• [Journal Article] Factors that are related to reduced visual acuity in male junior high school students and their effects : findings based on cross-sectional study (2010)
  • Author(s): Kaba, Y., Kawaguchi, A., Yanagawa, T.
  • Journal Title: Japanese Journal of Public Health Volume: Volume 57 Issue 3 Pages: 165-174
  • NAID: 130004626262
  • Peer Reviewed
• [Journal Article] Multivariate Mann-Whitney Estimators for the Comparison of Two Treatments in a Three Period Crossover Study with Randomly Missing Data (2010)
  • Author(s): Kawaguchi, A.
  • Journal Title: Journal of Biopharmaceutical Statistics Volume: 20 Pages: 720-744
  • Peer Reviewed
• [Journal Article] Statistical Inference for Independent Component Analysis Based on Polynomial Spline Model (2010)
  • Author(s): Kawaguchi A.
  • Journal Title: Lecture Notes in Engineering and Computer Science : Proceedings of The International MultiConference of Engineers and Computer Scientists 2010, IMECS 2010 Pages: 478-480
  • Peer Reviewed
• [Journal Article] Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease (2010)
  • Author(s): Sen S., et al.
  • Journal Title: Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] Factors that are related to reduced visual acuity in male junior high school students and their effects ; findings based on cross-sectional study (2010)
  • Author(s): Kaba Y., et al.
  • Journal Title: Japanese Journal of Public Health (in press)
  • Peer Reviewed
• [Presentation] Assessing systemic effects in bilateral crossover design (2012)
  • Author(s): Kawaguchi A. and Koch, G. G.
  • Organizer: The 3rd East Asia Regional Biometric Conference 2012
  • Place of Presentation: Seoul, Korea
• [Presentation] 認知症早期発見のための三次元脳画像に基づく関数データ解析 (2011)
  • Author(s): 荒木由布子, 川口淳, 山下典夫
  • Organizer: 2011年度統計関連学会連合大会
  • Place of Presentation: 九州大学
  • Year and Date: 2011-09-07
• [Presentation] 関数データ解析の三次元脳画像解析への応用 (2011)
  • Author(s): 川口淳, 荒木由布子, 山下典夫
  • Organizer: 日本計算機統計学会第25回大会
  • Place of Presentation: 函館市
  • Year and Date: 2011-05-08
• [Presentation] The early detection of Alzheimer's diseases based on MRI data via sparse functional logistic classification (2011)
  • Author(s): Araki Y. Kawaguchi A. and Yamashita F
  • Organizer: Joint Meeting of the 2011
  • Place of Presentation: Taipei, Taiwan
• [Presentation] 拡張二変量順位和統計量の2期2剤4群クロスオーバー試験への応用 (2010)
  • Author(s): 川口淳
  • Organizer: 2010年度統計関連学会連合大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2010-09-08
• [Presentation] 拡張二変量順位和統計量の2期2剤4群クロスオーバー試験への応用 (2010)
  • Author(s): 川口淳
  • Organizer: 2010年度 統計関連学会連合大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2010-09-08
• [Presentation] Stratified Multivariate Mann-Whitney Estimators for the Comparison of Two Treatments with Randomization Based Covariance Adjustment (2010)
  • Author(s): Kawaguchi A., Koch, G. G. Wang X.
  • Organizer: The 31st ISCB Annual Conference
  • Place of Presentation: Montpellier, France
  • Year and Date: 2010-08-29
• [Presentation] 層別多変量マンホイットニー推定量による2種類の治療法の比較 (2010)
  • Author(s): 川口淳, Koch, G. G. WangX
  • Organizer: 日本計量生物学会年会
  • Place of Presentation: 統計数理研究所
  • Year and Date: 2010-05-21
• [Presentation] Statistical Inference for Independent Component Analysis Based on Polynomial Spline Model (2010)
  • Author(s): Kawaguchi A
  • Organizer: The International MultiConference of Engineers and Computer Scientists 2010
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-03-18
• [Presentation] Statistical Inference for Independent Component Analysis Based on Polynomial Spline Model (2010)
  • Author(s): 川口淳
  • Organizer: The International MultiConference of Engineers and Computer Scientists 2010, IMECS 2010
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-03-18
• [Presentation] 多項スプラインモデルによる独立成分分析とその推測 (2009)
  • Author(s): 川口淳
  • Organizer: 日本計算機統計学会第23回シンポジウム
  • Place of Presentation: 札幌学院大学
  • Year and Date: 2009-11-08
• [Presentation] 多項スプラインモデルによる独立成分分析とその推測 (2009)
  • Author(s): 川口淳
  • Organizer: 日本計算機統計学会第23回シンポジウム
  • Place of Presentation: 札幌学院大
  • Year and Date: 2009-11-08
• [Presentation] fMRIデータにおける多項スプライン型独立成分分析 (2009)
  • Author(s): 川口淳
  • Organizer: 第11回ブレインサイエンス研究会
  • Place of Presentation: 福岡県柳川市
  • Year and Date: 2009-06-07
• [Patent(Industrial Property Rights)] 中枢神経原発悪性リンパ腫患者の予後予測方法、キット、遺伝子セット及び使用 (2011)
  • Inventor(s): 山中龍也,岩立康男,藤井幸彦,角間辰之,川口淳,梶原浩司
  • Industrial Property Rights Holder: 京都府立医科大学,千葉大学,新潟大学,久留米大学,山口大学
  • Industrial Property Number: 2011-154664
  • Filing Date: 2011-07-13
• [Patent(Industrial Property Rights)] 中枢神経原発悪性リンパ腫患者の予後予測方法、キット、遺伝子セット及び使用 (2011)
  • Inventor(s): 山中龍也, 岩立康男, 藤井幸彦, 角間辰之, 川口淳, 梶原浩司
  • Industrial Property Rights Holder: 京都府立医科大学, 千葉大学, 新潟大学, 久留米大学, 山口大学
  • Industrial Property Number: 2011-154664
  • Filing Date: 2011-07-13
• [Patent(Industrial Property Rights)] 悪性神経膠腫患者の予後予測方法 (2010)
  • Inventor(s): 山中龍也・川口淳・角間辰之
  • Industrial Property Rights Holder: 久留米大学
  • Industrial Property Number: 2010-084929
  • Filing Date: 2010-04-01