| Project/Area Number |
21700321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | National Institute of Biomedical Innovation |
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Principal Investigator |
MORITA Mizuki National Institute of Biomedical Innovation, 創薬基盤研究部, 研究員 (00519316)
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| Research Collaborator |
IKEZAWA Hiroki 東京大学, 大学院・農学生命科学研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | タンパク質による分子認識 / タンパク質 / 分子認識 / リガンド / 相互作用 / 相互作用部位 / 四次構造 |
|---|
| Research Abstract |
Protein-ligand interaction is a basic process underlying diverse biological phenomena. The ultimate goal of this project is to reveal how the location of ligand binding sites on protein surface have been selected in the course of evolution. We have developed a dataset of protein quaternary structures with ligands. We then have taken the statistics of the location of ligand binding sites, and have analyzed the relationships between the location and geometric feature of the ligand binding site, protein dynamics and protein function, respectively.
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