| Project/Area Number |
21700325
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kagawa University |
|---|
Principal Investigator |
KITAJIMA Hiroyuki Kagawa University, 工学部, 准教授 (90314905)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 力学系 / 分岐 / システムバイオロジー / 交互脈 / システム・バイオロジー / 数理モデル |
|---|
| Research Abstract |
Electrical alternans is alternating amplitude from beat to beat in the action potential for the cardiac cell. It has been associated with ventricular arrhythmias in many clinical studies. In this study, we construct a simple network model of the heart system. Using this model, we clarify that two parameters (the conductance of the sodium ion and free concentration of the potassium ion in the extracellular compartment) play key roles of generating alternans. This result indicates that if the muscle cell has some problems such as channelopathies, then there is great risk of occurring alternans.
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