| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Our results suggest the longitudinal lacking (lola)gene, encoding putative transcription factors of the BTB-Zn-finger family, plays an essential role to generate the sexual differences in neuronal structures and behavior by producing sexually dimorphic transcription factors. In males, Lola acts as a transcriptional cofactor of Fru, the male-specific sex determination factor that masculinizes subsets of neurons that govern courtship behavior. In females, Lola controls female-specific neurite formation in a fru-independent manner. Collectively, lola might acquire its ability to orchestrate sexual development of the entire brain by producing hundreds of Lola isoforms each with potentially different target specificity.
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