Regulation, maintenance, and plasticity of central dopaminergic synapses
Project/Area Number |
21700347
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neuroscience in general
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
TOKUOKA Hirofumi 東京工業大学, 大学院・生命理工学研究科, 助教 (10452020)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ドーパミン / 黒質 / 線条体 / 大脳基底核 / チロシン水酸化酵素 / 遺伝子ノックアウトマウス / ノックアウトマウス / アデノ随伴ウイルス / アデノ随伴ウィルス |
Research Abstract |
The tyrosine hydroxylase(TH) gene, essential for dopamine synthesis, is partially ablated in adult nigrostriatal projection. TH reduction in axon terminals is slower than in soma, and dopamine is better maintained than TH. Our data suggest striatal dopamine is compensatorily regulated by axonal TH level and L-DOPA synthesis activity per TH level. This regulation has potential relevance to pathogenesis of Parkinson disease and other dopamine-related psychiatric disorders.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection2011
Author(s)
Tokuoka, H., Muramatsu, S., Sumi- Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D., and Ichinose, H.
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Journal Title
Journal of Biological Chemistry
Volume: 286
Issue: 50
Pages: 43549-43558
DOI
Related Report
Peer Reviewed
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