Molecular mechanism of long-term synaptic plasticity at cerebellar inhibitory synapses
Project/Area Number |
21700349
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neuroscience in general
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Research Institution | Kyoto University |
Principal Investigator |
KAWAGUCHI Shin-Ya Kyoto University, 大学院・理学研究科, 助教 (00378530)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | シナプス可塑性 / パッチクランプ / システム生物学 / GABARAP / CaMKII / GABA / シミュレーション / 抑制性シナプス / 可塑性 / GABA(A)受容体 / Ca^<2+> |
Research Abstract |
At GABAergic synapses on a cerebellar Purkinje neuron, long-term potentiation of inhibitory synaptic transmission mediated by GABA(A) receptors is induced by postsynaptic depolarization. Using electrophysiological and fluorescent imaging experiments coupled with systems biological simulation, this study revealed that neuronal activity-dependent sustained activation of CaMKII leads to stable modification of GABARAP self-association, contributing to the long-term maintenance of inhibitory synaptic LTP.
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Report
(3 results)
Research Products
(15 results)