| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
This study aims to clarify the role of neuronal activity in circuit formation of the mammalian cerebral cortex. Levels and patterns of activity in mouse layer 2/3 cortical neurons during the perinatal period were manipulated in vivo, and their morphological development was assessed. Reducing activity in layer 2/3 neurons disturbed their long-range axonal projections. This defect was restored by increasing activity, suggesting that neuronal activity plays a pivotal role in their long-range axonal projections. In addition, repressing expression or function of an ion channel that is shown to be associated with an inherited mental retardation disturbed neuronal migration. Results suggest that control of neuronal activity is crucial for cortical circuit formation.
|
