Construction of a computational model for gait disorder using neuronal oscillators controlled by the cortico-basal ganglia loop

• Project/Area Number: 21700353
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kyushu University
• Principal Investigator: OKAMOTO Tsuyoshi 九州大学, 医学研究院, 准教授 (90432913)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 計算論的神経科学 / 歩行モデル / 歩行障害 / パーキンソン病 / 大脳基底核

Research Abstract

In this study, we developed a computational model of human gait based on the cortico-basal ganglia loop circuit. The model reproduced gait patterns of normal subjects and patients with Parkinson' s disease(PD). First, we calculated quantitative indices on gait patterns, and characterized the differences between young healthy subjects and elderly healthy subjects and between elderly healthy subjects and elderly PD patients. Second, we constructed the computational model consisting of the cortico-basal ganglia loop and neuronal oscillators. The computer simulation using this model reproduced the gait motion of the legs of elderly healthy subjects and elderly PD patients, respectively. We confirmed that the cortico-basal ganglia loop could change the gait control.

Research Products

• [Journal Article] Construction of Brain Simulator System for Computer-aided Progress Overview FY2011 Diagnosis and Therapy (2012)
  • Author(s): Miyagi Y, Morooka K, Fukuda T, Okamoto T, Sunagawa K.
  • Journal Title: The 3rd International Symposium on Computational Anatomy Pages: 108-109
  • Peer Reviewed
• [Journal Article] Discrimination analysis of gait in normal aging and Parkinson' s disease (2011)
  • Author(s): Tsuyoshi OKAMOTO, Yoshitaka NAKANISHI, Katsuya OGATA, Etsuo GENDA, Akifumi MAKINOUCHI, Shozo TOBIMATSU.
  • Journal Title: Proceedings of the 3rd International Symposium on Digital Manufacturing Pages: 179-184
  • Peer Reviewed
• [Journal Article] Three-dimensional Reconstruction of Human Brain Histological Section and the Development of Digital Brain Atlas of the Japanese (2011)
  • Author(s): Yasushi Miyagi, Kenichi Morooka, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Xian Chen, Takehito Hayami.
  • Journal Title: Proceedings of the 3rd International Symposium on Digital Manufacturing Pages: 153-158
  • Peer Reviewed
• [Journal Article] Discrimination analysis of gait in normal aging and Parkinson's disease (2011)
  • Author(s): Tsuyoshi OKAMOTO, et al
  • Journal Title: Proceedings of the 3rd International Symposium on Digital Manufacturing Pages: 179-184
  • Peer Reviewed
• [Journal Article] Spectral analysis of field potential recordings by DBS electrode for localization of subthalamic nucleus in patients with Parkinson' s disease (2009)
  • Author(s): Yasushi Miyagi, Tsuyoshi Okamoto, Takato Morioka, Shozo Tobimatsu, Yoshitaka Nakanishi, Kazuyuki Aihara, Kimiaki Hashiguchi, Nobuya Murakami, Fumiaki Yoshida, Kazuhiro Samura, Shinji Nagata, Tomio Sasaki
  • Journal Title: Stereotactic and Functional Neurosurgery Volume: 87 Pages: 211-218
  • Peer Reviewed
• [Journal Article] Short circuit in deep brain stimulation
  • Author(s): Kazuhiro Samura, Yasushi Miyagi, Tsuyoshi Okamoto, Takehito Hayami, Mitsuo Katano, Kazufumi Kamikaseda.
  • Journal Title: Journal of Neurosurgery Volume: in press
  • Peer Reviewed
• [Presentation] Clinical implication of short circuit in DBS (2012)
  • Author(s): Miyagi Y, Samura K, Okamto T, Hayami T.
  • Organizer: The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting(AASSFN 2011)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2012-06-18
• [Presentation] onstruction of Brain Simulator System for Computer-aided Diagnosis and Therapy (2012)
  • Author(s): Miyagi Y, Morooka K, Fukuda T, Okamoto T, Sunagawa K
  • Organizer: Construction of Brain Simulator System for Computer-aided Diagnosis and Therapy : Progress Overview FY2011
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Discrimination analysis of gait in normal aging and Parkinson's disease (2011)
  • Author(s): Tsuyoshi OKAMOTO, et al
  • Organizer: The 3rd International Symposium on Digital Manufacturing (ISDM) 2011
  • Place of Presentation: リーガロイヤルホテル小倉(北九州市)
  • Year and Date: 2011-12-01
• [Presentation] Discrimination analysis of gait in normal aging and Parkinson' s disease (2011)
  • Author(s): Tsuyoshi OKAMOTO, Yoshitaka NAKANISHI, Katsuya OGATA, Etsuo GENDA, Akifumi MAKINOUCHI, Shozo TOBIMATSU
  • Organizer: The 2011 International Symposium on Digital Manufacturing(ISDM2011)
  • Place of Presentation: Kitakyushu, Japan
• [Presentation] hree-dimensional Reconstruction of Human Brain Histological Section and the Development of Digital Brain Atlas of the Japanese (2011)
  • Author(s): Yasushi Miyagi, Kenichi Morooka, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Xian Chen, Takehito Hayami
  • Organizer: Proceedings of the 3rd International Symposium on Digital Manufacturing(ISDM2011)
  • Place of Presentation: Kitakyushu, Japan
• [Presentation] パーキンソン病患者の定量的歩行評価 (2010)
  • Author(s): 岡本剛
  • Organizer: 非線形・非平衡動力学ワークショップ
  • Place of Presentation: 鹿児島大
  • Year and Date: 2010-10-16
• [Presentation] パーキンソン病患者の定量的歩行評価 (2010)
  • Author(s): 岡本剛
  • Organizer: 非線形・非平衡動力学ワークショップ
  • Place of Presentation: 鹿児島大学
  • Year and Date: 2010-10-16