Regulation of differentiation/maturation of neocortical neurons after radial migration
| Project/Area Number |
21700356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
OISHI Koji 慶應義塾大学, 医学部, 特任助教 (80420818)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 大脳皮質 / 層構造 / 発生・分化 |
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| Research Abstract |
Neural precursor cells in the neocortex give rise to distinct subtypes of six-layered neurons, which posses different characteristics. It has been thought that subtype specification of these neurons occurs when the precursor cells undergo final mitosis. However, our group recently found that subtype specification of layer IV neurons occurred at later stages, when the neurons already finished their radial migration. In this study, I tried to explore the mechanisms of subtype specification of layer IV neurons after neuronal migration and found that thalamocortical axons played an important role in this process.
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Report
(3 results)
Research Products
(17 results)
