Molecular mechanisms underlying COUP-TFI/II-mediated temporal identity transition of neural stem cells
| Project/Area Number |
21700357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research (2011)
Keio University (2009-2010) |
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Principal Investigator |
KANEDA Hayato 独立行政法人理化学研究所, 免疫転写制御研究グループ, 上級研究員 (40528212)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | グリア / 再生医学 / 時間特異性 / 神経幹細胞 / 神経発生 / 神経科学 / 脳・神経 / 再生 / competence / 幹細胞老化 |
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| Research Abstract |
I succeeded in identification of the downstream effector of COUP-TFs and elucidation of the major molecular mechanisms underlying the neurogenic-to-gliogenic transition of developing neural stem cells. Furthermore, control of the effector enabled us to control the neural stem cell competence bi-directionally, neurogenic or gliogenic. These findings will greatly contribute to the clinical applications of neural stem cells for the treatment of CNS injury and disease.
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Report
(4 results)
Research Products
(15 results)
