RNA-binding protein Musashi1-mediated miRNA regulation
Project/Area Number |
21700358
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Neuroscience in general
|
Research Institution | Keio University |
Principal Investigator |
KAWAHARA Hironori Keio University, 医学部, 助教 (00424177)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | Musashi1 / let-7 / Lin28 / 幹細胞 / ES細胞 / Musashil / Let-7 / 脳・神経 / 発現制御 / miRNA |
Research Abstract |
Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem/progenitor cells (NS/PCs) as well as in other tissue stem cells. I showed that Msi1 works in concert with Lin28 to regulate post-transcriptional miRNA biogenesis in the cropping step, which occurs in the nucleus. Also, I found that Msi1 enhanced the localization of Lin28 to the nucleus and also inhibited the nuclear cropping step of another let-7 family miRNA, miR98.
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Report
(3 results)
Research Products
(12 results)