Regulation of synaptic plasticity through inter-GPCR interplay
Project/Area Number |
21700359
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Neuroscience in general
|
Research Institution | Juntendo University |
Principal Investigator |
KAMIKUBO Yuji Juntendo University, 医学部, 助教 (80509670)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 分子 / 細胞神経科学 / Gタンパク質共役型受容体 / シナプス伝達 / 代謝型グルタミン酸受容体 / アデノシン受容体 / 長期抑圧 / 小脳 / シナプス可塑性 / シグナル・クロストーク / mGluR1 / アデノシンA1受容体 / GABA_B受容体 |
Research Abstract |
In this project, I showed functional interaction of type-1 metabotropic glutamate receptor (mGluR1) with adenosine A1 receptor (A1R). A1R signaling modulates synaptic release and neuronal excitability in many neurons. mGluR1 is a key molecule for inducing long-term depression. I found co-localization of A1R and mGluR1 in the plasma membrane. A1R agonists attenuated mGluR1-signaling and abolished LTD of glutamate-evoked current in cultured Purkinje cells
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Report
(3 results)
Research Products
(13 results)