The importance of myelin in the regulation of axonal mitochondria

• Project/Area Number: 21700361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: ISHIBASHI Tomoko 東京薬科大学, 薬学部, 助教 (50453808)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 髄鞘(ミエリン) / オリゴデンドロサイト / ミトコンドリア / 軸索 / ミエリン / パラノーダルジャンクション / 小脳 / IP3R1 / 軸索輸送

Research Abstract

Vertebrate myelinated axons propagate electrical impulse rapidly by salutatory conduction. Paranodal axo-glial junctions play a crucial role in the organization and maintenance of molecular domains in myelinated axons. Cerebroside sulfotransferase(CST) deficient mice show disruption of the paranodal axo-glial junction both in the CNS and the PNS. We reported that axonal mitochondria at the nodes of Ranvier were large and swollen, and that axonal transport related protein levels decreased in the PNS of CST-deficient mice. We also found that the finding of frequent focal axonal swellings in the cerebellar Purkinje neurons.

Research Products

• [Journal Article] Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice (2011)
  • Author(s): Kajigaya H, Tanaka KF, Hayashi A, Suzuki A, Ishibashi T, Ikenaka K, Baba H
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 87(7) Pages: 415-424
  • NAID: 130001066428
  • URL: http://dx.doi.org/10.2183/pjab.87.415
• [Journal Article] Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice (2011)
  • Author(s): Kajigaya H, Tanaka KF, Hayashi A, Suzuki A, Ishibashi T, Ikenaka K, Baba H
  • Journal Title: Proceedings of the Japan Academy Volume: 87 Pages: 415-424
  • NAID: 130001066428
  • Peer Reviewed
• [Journal Article] Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve (2009)
  • Author(s): Ishibashi T, Lee PR, Baba H, Fields RD
  • Journal Title: Journal of Neuroscience research Volume: 58 Issue: 15 Pages: 752-764
  • DOI: 10.1002/jnr.22173
• [Journal Article] Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve (2009)
  • Author(s): 石橋智子, Lee PR, 馬場広子, Fields RD.
  • Journal Title: Joumal of Neuroscience research 58 Pages: 752-764
  • Peer Reviewed
• [Presentation] パラノーダルジャンクション形成不全時における小脳プルキンエ細胞の変化 (2011)
  • Author(s): 石橋智子, 馬場広子
  • Organizer: 第54回日本神経科化学会
  • Place of Presentation: 石川県・山代温泉・瑠璃光
  • Year and Date: 2011-09-27
• [Presentation] Disruption of axo-glial interaction causes focal axonal damages in cerebellar Purkinje neurons (2011)
  • Author(s): Ishibashi T, Baba H
  • Organizer: 10^<th> Biennial ISN Satellite Meeting on Myelin Biology
  • Place of Presentation: Kolymvari, Creta, Greece
• [Presentation] 末梢神経系パラノーダル・ジャンクション形成異常における軸索の変化 (2009)
  • Author(s): 児玉明子, 石橋智子, 馬場広子
  • Organizer: 第52会日本神経化学会
  • Place of Presentation: 伊香保温泉ホテル天坊(群馬)
• [Remarks]
  • URL: http://www.ps.toyaku.ac.jp/kino-keitai/youkoso.html