| Project/Area Number |
21700364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SUZUKI Ryoko National Institute for Basic Biology, 統合神経生物学研究部門, 特別協力研究員 (60414017)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経回路形成 / 軸索側枝 / 神経栄養因子 / ニワトリ |
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| Research Abstract |
SPIG1 is a secretory molecule of unknown function, which is composed of a follistatin-like domain, an extracellular calcium-binding domain, and two immunoglobulin-like domains. I have here investigated the role of SIPIG1 during the branch formation, elaboration of axon terminals and synaptic formation in retinal axons. I found that SIPIG1 interacts with one of a neurotrophic receptor. I also investigated the possibility that SPIG1 is involved in synaptic formation during development. In SPIG1 knock-down dorsalretina, the superficial layers of the optic tectum were thin. However, the synapse structure and synaptic positions were normal. These results indicate that SPIG1 is involved in branch formation and refinement of developing retinal axons, and also SPIG1 might function as an axonally secreted regulator of the local extracellular proteolysis involved in the innervation by retinal axons within the tectum.
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