Developmental analysis of the neural activity in the left and right hemispheres using zebrafish
| Project/Area Number |
21700370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
AIZAWA Hidenori 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 客員主管研究員 (80391837)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 左右差 / 非対称性 / 手綱核 / ゼブラフィッシュ / 左右非対称 / 電気穿孔法 / GFP / 光学的測定 / 共焦点顕微鏡 / 手綱 / カルシウム |
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| Research Abstract |
We focused on the zebrafish habenular circuit showing the left-right asymmetry in the projection pattern to study the difference in neural connectivity and its activity between left and right hemispheres. Through the analyses, we were able to 1) visualize the difference in the activity of the cells in the left and right habenula with calcium imaging, 2) identify the fish homologue of mammalian medial and lateral habenulae by the hodological and gene expression analyses and 3) identify the output pathway of the interpeduncular nucleus which receives asymmetric projection from the dorsal habenula.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] The habenula is crucial for experience-dependent modification of fear responses in zebrafish2010
Author(s)
Agetsuma A, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S and Okamoto H
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Journal Title
Nat Neurosci
Volume: 13(11)
Pages: 1354-6
Related Report
Peer Reviewed
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