| Project/Area Number |
21700373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMANAKA Tomoyuki The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員 (00381575)
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|---|
| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 転写印紙 / NF-Y / 神経細胞 / ノックアウトマウス / 神経変性 / 転写因子 / 中枢神経 / 神経分化・変性 |
|---|
| Research Abstract |
To investigate physiological function of NF-Y transcription factor in nervous system, we made neuron-specific NF-YA (one of NF-Y components) conditional knockout mice. Although the knockout mice could be born, increase in body weight was severely affected, resulting in neonatal death. We further identified many potential NF-Y target genes involved in gene transcription/translation and protein folding/degradation by ChIP on CHIP analysis using mouse brain. Thus, NF-Y-mediated expression of these genes in neuron may be important for neonatal mouse development.
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