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Development of new model to examine LTM formation in vitro

Research Project

Project/Area Number 21700376
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research Institution財団法人東京都医学研究機構 (2010)
Tokyo Metropolitan Organization for Medical Research (2009)

Principal Investigator

UENO Kohei  財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (40332556)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords分子 / 細胞神経科学 / ショウジョウバエ / イメージング / 学習記憶 / 可塑性 / ショウジョウバェ
Research Abstract

The physiological mechanisms of memory formation and storage is still unclear. In this report, I tried to examine the mechanisms by using isolated brain of Drosophila melanogaster. I found that the fly brain expressing fluorescent probe to monitor neural activity responded by electrical stimulation. Finally, I found that the electrical stimulation successfully induced the neural plasticity associate odor-avoidance memory in fly. By some experiments, I propose the new neural model to explain the odor-avoidance memory.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse.2010

    • Author(s)
      Kuromi H, Ueno K, Kidokoro Y.
    • Journal Title

      Eur.J.Neurosci. 32(3)

      Pages: 335-346

    • Related Report
      2010 Final Research Report
  • [Journal Article] Two types of Ca^<2+> channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse.2010

    • Author(s)
      Kuromi H, Ueno K, Kidokoro Y.
    • Journal Title

      European Journal of Neuroscience

      Volume: 32(3) Pages: 335-346

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 記憶学習の精緻な理解に向けてのモデル動物:ハエ2010

    • Author(s)
      上野耕平・齊藤実
    • Journal Title

      生体の科学 61(1)

      Pages: 17-23

    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子と行動を繋ぐ脳機能の蛍光イメージング解析2010

    • Author(s)
      上野耕平
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸コンベンションセンター(招待講演)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一過性ドパミン処理はキノコ体ニューロンの反応性を増強させる2010

    • Author(s)
      上野耕平
    • Organizer
      第33回日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] -過性ドパミン処理はキノコ体ニューロンの反応性を増強させる2010

    • Author(s)
      上野耕平、齊藤実
    • Organizer
      第33回日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝子と行動を繋ぐ脳機能の蛍光イメージング解析(ワークショップ:行動は遺伝子にどこまで規定されるか)2010

    • Author(s)
      上野耕平、齊藤実
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional imaging analysis in the cultured Drosophila brain using high-speed scanning confocal microscopy.2009

    • Author(s)
      上野耕平
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 培養ショウジョウバエ脳における神経応答の高速スキャニング共焦点レーザー顕微鏡による可視化2009

    • Author(s)
      上野耕平、齊藤実
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際センター
    • Related Report
      2010 Final Research Report
  • [Book] 生体の科学,61(1)2010

    • Author(s)
      上野耕平、齊藤実
    • Publisher
      記憶学習の精緻な理解に向けてのモデル動物:ハエ
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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