| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The R553H mutation has been found in the FOXP2 gene of patients with speech-language disorder. Foxp2(R552H) knock-in(KI) mice exhibit impaired ultrasonic vocalization(USV), which is related to human speech and language, and abnormal Purkinje cell development. To clarify the relationship between Foxp2 function in Purkinje cells and USV, we prepared transgenic(Tg) mice that express Foxp2-myc in Purkinje cells. Foxp2 expression in the cerebellum of heterozygous Foxp2(R552H)-KI{Foxp2(R552H)-KI-Pcp2-FOXP2-myc-Tg} mice improved USVs and increased whistle-like sounds. Foxp2 expression promoted dendrite formation in Purkinje cells.
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