The regulation of mouse ultrasonic vocalization and behavior by Foxp2
| Project/Area Number |
21700377
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
JIMBO Eriko 自治医科大学, 医学部, 講師 (20291651)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | Foxp2 / 超音波音声 / マウス / 脳 / 言語障害 |
|---|
| Research Abstract |
The R553H mutation has been found in the FOXP2 gene of patients with speech-language disorder. Foxp2(R552H) knock-in(KI) mice exhibit impaired ultrasonic vocalization(USV), which is related to human speech and language, and abnormal Purkinje cell development. To clarify the relationship between Foxp2 function in Purkinje cells and USV, we prepared transgenic(Tg) mice that express Foxp2-myc in Purkinje cells. Foxp2 expression in the cerebellum of heterozygous Foxp2(R552H)-KI{Foxp2(R552H)-KI-Pcp2-FOXP2-myc-Tg} mice improved USVs and increased whistle-like sounds. Foxp2 expression promoted dendrite formation in Purkinje cells.
|
Report
(4 results)
Research Products
(12 results)
