| Project/Area Number |
21700381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Osaka University |
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Principal Investigator |
UENO Masaki Osaka University, 大学院・医学系研究科, 助教 (40435631)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大脳損傷 / 神経回路 / 可塑性 / 皮質脊髄路 / 運動機能 / 自然回復 / 脳損傷 / 代償性神経回路 / 脊髄介在ニューロン / シエリン / ミエルン |
|---|
| Research Abstract |
Brain injury that results in an initial behavioral deficit is frequently followed by spontaneous functional recovery. In the present study, we showed that reorganization of the remnant neural network was crucial for spontaneous recovery of motor function following brain injury in mice. Furthermore, we identified several key signals (BDNF-TrkB, GABA, EphA4-EphrinB3, MAG/Nogo/OMgp-PirB) that modify this new network formation.
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