The analysis of Reelin-Dab1 signaling pathway for dendrite formation and guidance

• Project/Area Number: 21700383
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: HONDA Takao 慶應義塾大学, 医学部, 助教 (30365225)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経発生 / 分化 / 異常 / reelin / dab1 / reeler / yotari / 樹状突起

Research Abstract

As we found that Dab1 is involved in dendrite formation and can translocate into nucleus, we hypothesized that Reelin regulates an expression of dendrite formation related genes through the Dab1 nuclear translocation. When we coexpressed dab1 knockdown ve

Research Products

• [Journal Article] Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway (2011)
  • Author(s): Takao Honda, Kazuma Kobayashi, Katsuhiko Mikoshiba, Kazunori Nakajima
  • Journal Title: Neurochemical Research Volume: 36 Pages: 1270-9
  • URL: http://dx.doi.org/10.1007/s11064-011-0407-4
  • Peer Reviewed
• [Journal Article] The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex (2011)
  • Author(s): Katsutoshi Sekine, Takao Honda, Takeshi Kawauchi, Ken-ichiro Kubo,Kazunori Nakajima.
  • Journal Title: The Journal of Neuroscience Volume: 31 Pages: 9426-39
  • URL: http://dx.doi.org/10.1523/JNEUROSCI.0650-11.2011
  • Peer Reviewed
• [Journal Article] Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway (2011)
  • Author(s): Honda T, Kobayashi K, Mikoshiba K, Nakajima K
  • Journal Title: Neurochem Res Volume: 36(7) Issue: 7 Pages: 1270-1279
  • DOI: 10.1007/s11064-011-0407-4
  • Peer Reviewed
• [Journal Article] The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex (2011)
  • Author(s): Sekine K, Honda T, Kawauchi T, Kubo K, Nakajima K
  • Journal Title: J Neurosci Volume: 31 Issue: 25 Pages: 9426-39
  • DOI: 10.1523/jneurosci.0650-11.2011
  • Peer Reviewed
• [Presentation] Analysis of the nucleocytoplasmic shuttling of Dab1 required for cortical structure formation(脳の皮質形成を制御するDab1の核移行メカニズムの解析) (2011)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 加賀
• [Presentation] Analysis of the nucleocytoplasmic shuttling of Dab1 required for cortical structure formation（脳の皮質形成を制御するDab1の核移行メカニズムの解析） (2011)
  • Author(s): 本田岳夫
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 加賀
• [Presentation] 大脳皮質層形成を制御するDab1 の核移行メカニズムの解析(Analysis of the nuclear translocation mechanism of Dab1 required for layer formation of the cerebral cortex) (2010)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸
• [Presentation] Analysis of the role of Dab1-nucleocytoplasmic shuttling for layer formation of cerebral cortex (Dab1 の核細胞質間シャトリングが大脳皮質層形成に果たす役割の解明) (2009)
  • Author(s): 本田岳夫、山崎真弥、長澤寿磨、阿部学、崎村建司、仲嶋一範
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川(伊香保)
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~Nakajima/index.html