Semaphorin signaling in the central olfactory projections

• Project/Area Number: 21700387
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute of Genetics
• Principal Investigator: KAWASAKI Takahiko 国立遺伝学研究所, 総合遺伝研究系, 助教 (00322751)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経回路網 / 軸索ガイダンス / 神経回路 / セマフォリンシグナル

Research Abstract

From studies of central olfactory projections using mice deficient for several molecules of semaphorin signaling, I found that several semaphorin signaling guide the projections cell-autonomously and non-cell-autonomously.

Research Products

• [Journal Article] The temporal sequence of the mammalian neocortical neurogenetic program drives mediolateral pattern in the chick pallium (2012)
  • Author(s): Suzuki, I. K., Kawasaki, T., Gojobori, T. and Hirata, T.
  • Journal Title: Dev. Cell Volume: Vol.22 Pages: 863-870
  • Peer Reviewed
• [Journal Article] Guidepost neurons for the lateral olfactory tract : expression of metabotropic glutamate receptor 1 and linnervation by glutamatergic olfactory bulb axons (2012)
  • Author(s): Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y. and Fukuda, A.
  • Journal Title: Dev. Neurobiol Volume: (in press) Issue: 12 Pages: 1559-1576
  • DOI: 10.1002/dneu.22030
  • Peer Reviewed
• [Journal Article] The Temporal Sequence of the Mammalian Neocortical Neurogenetic Program Drives Mediolateral Pattern in the Chick Pallium (2012)
  • Author(s): Suzuki, I.
  • Journal Title: Developmental Cell Volume: 22 Issue: 4 Pages: 1-8
  • DOI: 10.1016/j.devcel.2012.01.004
  • Peer Reviewed
• [Journal Article] Guidepost Neurons for the Lateral Olfactory Tract : Expression of Metabotropic Glutamate Receptor 1 and Innervation by Glutamatergic Olfactory Bulb Axons (2012)
  • Author(s): Hirata, T.
  • Journal Title: Developmental Neurobioligy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Cartilage acidic protein-1B(LOTUS), an endogenous Nogo receptor antagonist for axon tract formation (2011)
  • Author(s): Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, S. M., Goshima, Y. and Takei, K.
  • Journal Title: Science Volume: Vol.333 Issue: 6043 Pages: 769-773
  • DOI: 10.1126/science.1204144
  • Peer Reviewed
• [Journal Article] Proteomics Analysis of the Temporal Changes in Axonal Proteins during Maturation (2010)
  • Author(s): Yamatani, H., Kawasaki, T., Mita, S., Inagaki, N. and Hirata, T.
  • Journal Title: Dev. Neurobiol Volume: 70 Issue: 7 Pages: 523-537
  • DOI: 10.1002/dneu.20794
  • Peer Reviewed
• [Journal Article] Proteomics analysis of the temporal changes in axonal proteins during maturation (2010)
  • Author(s): Yamatani, H.
  • Journal Title: Developmental Neurobiology (In press)
  • Peer Reviewed
• [Presentation] Distinct functions of PlnA family proteins in the central olfactory projection嗅覚中枢軸索投射におけるPlnAファミリー分子の機能 (2011)
  • Author(s): 川崎能彦、平田たつみ
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄
• [Presentation] 羊膜類の体幹部末梢神経系の進化Evolution of developmental plan for peripheral nervous system in amniote trunk region (2011)
  • Author(s): 川口将史, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Distinct functions of PlnA family proteins in the central olfactory tract (2011)
  • Author(s): 川崎能彦
  • Organizer: 日本発生生物学会
  • Place of Presentation: 沖縄
• [Presentation] Interaction of semaphorin signaling in thecentral olfactory projection (2010)
  • Author(s): 川崎能彦、平田たつみ
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
• [Presentation] Development of the nervous system in the turtle trunk region (2010)
  • Author(s): 川口将史, 他
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
• [Presentation] カメ体幹部における末梢神経系の発生機構:脊椎動物の神経系の進化Development of the peripheral nervous system in turtles ; with reference to the evolution of the vertebrate trunk region (2010)
  • Author(s): 川口将史, 他
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Interaction of Semaphorin signaling in the central olfactory projection (2010)
  • Author(s): 川崎能彦
  • Organizer: 日本発生生物学会
  • Place of Presentation: 京都
• [Presentation] Novel function of Nrp2 as an inhibitor of Sema3A signalingin the projection of olfactory bulb axons (2009)
  • Author(s): 川亜能彦、平田たつみ
  • Organizer: 第42回日本発生生物学会年会
  • Place of Presentation: 新潟
• [Presentation] 新規な軸索ガイダンス分子LOTUS LOTUS, anovel axon guidance molecule (2009)
  • Author(s): 佐藤泰史, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 嗅球軸索投射におけるNrp2のSemasAシグナル阻害作 (2009)
  • Author(s): 川崎能彦、平田たつみ
  • Organizer: Construction and reconstruction of the brain
  • Place of Presentation: 淡路
• [Presentation] 嗅球軸索投射におけるNrp2のSema3Aシグナル阻害作用 (2009)
  • Author(s): 川崎能彦
  • Organizer: 発生生物学会
  • Place of Presentation: 新潟
• [Presentation] Nobel function of Nrp2 as an inhibitor of Sema3A signaling in the projection of olfactory bulb axons (2009)
  • Author(s): 川崎能彦
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: Awaji Yumebutai
• [Presentation] 嗅球軸索投射におけるセマフォリンシグナルの機能 (2009)
  • Author(s): 川崎能彦
  • Organizer: 発生生物学会終期シンポジウム
  • Place of Presentation: 三島
• [Remarks]
  • URL: http://www.nig.ac.jp/section/hiratahitrata-j.html