Analysis of the gamma-secretase interactome and regulation mechanisms of the enzymatic activity.
Project/Area Number |
21700392
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | The University of Tokyo |
Principal Investigator |
WAKABAYASHI Tomoko The University of Tokyo, 大学院・医学系研究科, 助教 (20530330)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 脳神経疾患 / アルツハイマー病 |
Research Abstract |
In this study, we searched for γ-secretase interacting proteins using proteomic analysis, and screened for proteins that affected either enzymatic activity or subcellular localization ofγ-secretase. As a result, we identified tetraspanins and tetraspanin-associated proteins that have been known to form the lipid microdomain in the cellular membranes (called tetraspanin web or TEM). We found the possibility that tetraspanins and tetraspanin-associated proteins provide a platform for γ-secretase cleavage and regulate its enzymatic activity.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.2009
Author(s)
Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B.
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Journal Title
Nature Cell Biology 11
Pages: 1340-1346
Related Report
Peer Reviewed
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