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Analysis of the mechanism of Parkinson disease and drug development using the nematode C.elegans

Research Project

Project/Area Number 21700393
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokyo

Principal Investigator

KUWAHARA Tomoki  The University of Tokyo, 大学院・薬学系研究科, 特任研究員 (10533903)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsパーキンソン病 / α-synuclein / リン酸化 / 線虫 / 脳神経疾患 / 遺伝学 / 病理学
Research Abstract

α-Synuclein is a causative gene for familial Parkinson's disease and its protein product accumulates in the neurons of affected brains with phosphorylation at Ser129. Nematode C. elegans is suggested as a useful tool for the analysis of the molecular mechanisms of neurodegenerative diseases. We have studied the role of phosphorylation of α-synuclein in its neurotoxicity using nematodes expressing human α-synuclein. Our results suggest that the phosphorylation at Ser129 functions against α-synuclein neurotoxicity and downstream stress response by lowering its membrane-binding property. We also found that the present nematode model is useful in further screening for modifier genes or therapeutic drugs.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009

All Presentation (2 results) Book (4 results)

  • [Presentation] The analysis of the neurotoxicity of phosphorylation-mutant alpha-synuclein in C. elegans.2010

    • Author(s)
      桑原知樹、利根川玲奈、三谷昌平、岩坪威
    • Organizer
      4th East Asia C.elegans Meeting
    • Place of Presentation
      東京
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] The analysis of the neurotoxicity of phosphorylation-mutant α-synuclein in C.elegans2010

    • Author(s)
      桑原知樹
    • Organizer
      East Asia C.elegans Meeting
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Book] Brain Medical 22(2)2010

    • Author(s)
      宮下惇嗣、桑原知樹、岩坪威
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Final Research Report
  • [Book] Brain Medical2010

    • Author(s)
      宮下惇嗣、桑原知樹、岩坪威
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] Cognition and Dementia 8(3)2009

    • Author(s)
      桑原知樹、岩坪威
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Final Research Report
  • [Book] Cognition and Dementia2009

    • Author(s)
      桑原知樹、岩坪威
    • Publisher
      メディカルレビュー社
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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