Analysis of ALS2 function in motor neurons form common marmoset
Project/Area Number |
21700397
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Nerve anatomy/Neuropathology
|
Research Institution | Kitasato University (2011) Tokai University (2009-2010) |
Principal Investigator |
ASAKO Otomo 北里大学, 理学部, 講座研究員 (50535226)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | ALS / ALS2 / 筋萎縮性側索硬化症2型 / マーモセット / 運動ニューロン / ES細胞 |
Research Abstract |
To understand the molecular mechanisms underlying neuronal dysfunctionand celldeath caused by loss of ALS2, we tried togenerateALS2 deficient cellular model using marmoset ES cells. We succeededin determining ALS2 sequence in marmoset, and cloned siRNA-mediated ALS2down-regulatedmarmoset ES cells. By differentiating theseES clones, we will analyzethe function of ALS2 in primate motor neuron.
|
Report
(4 results)
Research Products
(20 results)