| Project/Area Number |
21700398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATSUMOTO Gen The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員 (50415303)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | オートファジー / p62 / タンパク質分解 / シクエストソーム / ユビキチン / SQSTM1 / ポリユビキチン / オートファゴソーム / アグリソーム |
|---|
| Research Abstract |
The specific phosphorylation of p62 in its ubiquitin-associated (UBA) domain, regulates the autophagic clearance of polyubiquitinated protein aggregate. This phosphorylated form of p62 binds to polyubiquitin chains with higher affinity, resulting in the efficient recruitment of polyubiquitinated proteins in the "sequestosomes" which are units of autophagosome entry. The phosphorylation in p62 regulates autophagic clearance of ubiquitinated proteins that are poorly degraded by proteasomes.
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