Chromatin Dynamics during Neuronal Differentiation

• Project/Area Number: 21700404
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: SUGO Noriyuki Osaka University, 大学院・生命機能研究科, 助教 (20372625)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 発生・分化・老化 / 遺伝子発現調節 / クロマチン / DNA修復 / 分子・細胞神経科学 / 発生・分化 / 大脳皮質 / ゲノム

Research Abstract

Molecular mechanism of neuronal differentiation including transcription and chromatin regulation has remained unclear. In this study, we revealed that that histone deacetylase (HDAC) and DNA repair protein play a critical role in cortical differentiation.

Research Products

• [Journal Article] A Molecular Mechanism That Regulates Medially Oriented Axonal Growth of Upper Layer Neurons in the Developing Neocortex. (2011)
  • Author(s): Hong Zhao, Takuro Maruyama, Yuki Hattori, Noriyuki Sugo, Hyota Takamatsu, Atsushi Kumanogoh, Ryuichi Shirasaki, Nobuhiko Yamamoto.
  • Journal Title: J Comp Neurol. 519 Pages: 834-848
  • Peer Reviewed
• [Journal Article] A Molecular Mechanism That Regulates Medially Oriented Axonal Growth of Upper Layer Neurons in the Developing Neocortex (2011)
  • Author(s): Hong Zhao, et al.
  • Journal Title: The Journal of Comparative Neurology Volume: 519 Pages: 834-848
  • Peer Reviewed
• [Journal Article] Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons. (2010)
  • Author(s): Noriyuki Sugo, Hiroaki Oshiro, Mitsuhiro Takemura, Toshiaki Kobayashi, Yusuke Kohno, Naofumi Uesaka, Wen-Jie Song, Nobuhiko Yamamoto.
  • Journal Title: Eur J Neurosci. 31 Pages: 1521-1532
  • Peer Reviewed
• [Journal Article] Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons (2010)
  • Author(s): Noriyuki Sugo, et al.
  • Journal Title: European Journal of Neuroscience Volume: 31 Pages: 1521-1532
  • Peer Reviewed
• [Presentation] 発生期大脳皮質の前駆細胞においてDNA修復酵素は転写活性と連動して集積する (2010)
  • Author(s): 菅生紀之, 至田充宏, 山本亘彦
  • Organizer: 第33回日本神経科学大会(Neuro2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] DNA repair enzymes form foci in cortical progenitor cells in association with transcription (2010)
  • Author(s): Noriyuki Sugo, et al.
  • Organizer: Neuro2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-02
• [Presentation] Activity-dependent nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth indeveloping cortical neurons (2009)
  • Author(s): Noriyuki Sugo, Hiroaki Oshiro, Mitsuhiro Takemura, Toshiaki Kobayashi, Yusuke Kohno, Naofumi Uesaka
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: Awaji Yumebutai
  • Year and Date: 2009-10-09
• [Presentation] Activity-dependent nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons (2009)
  • Author(s): Noriyuki Sugo, et al.
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: 淡路夢舞台(兵庫県)
  • Year and Date: 2009-10-09
• [Remarks] ホームページ等
  • URL: http://www.fbs.osaka-u.ac.jp/labs/neurobiol/
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/neurobiol/
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/neurobiol/