| Project/Area Number |
21700405
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
ISHIKAWA Yasuyuki Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (90346320)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | シナプス可塑性 / 連合記憶 / ニューロプシン / シナプス・タグ / 神経可塑性 / LTP / LTD / 海馬 / 記憶・学習 / シナプス・タギング / 記憶 / 学習 |
|---|
| Research Abstract |
Activity-dependent synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. Synaptic tagging and capture could be involved in activity-dependent synaptic plasticity, because it distinguishes between local mechanisms of synaptic tags and cell-wide mechanisms that are responsible for the synthesis of plasticity-related proteins. I found that a plasticity related serine protease, neuropsin, is involved in the tag-setting process during LTP at basal and apical dendritic inputs. Neuropsin is involved in synaptic tagging and cross-tagging during LTP at apical dendritic inputs via integrin beta-1 and CaMKII signaling.
|
