Regeneration of mind : Development of a novel treatment of psychiatric disorder caused by nurturing environment such as child abuse

• Project/Area Number: 21700406
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tottori University
• Principal Investigator: ICHISAKA Satoshi 鳥取大学, 医学部, 助教 (50359874)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 神経可塑性 / 成育環境 / 精神疾患 / 前頭前野 / 母子分離 / オープンフィールド / 不安様行動 / 前頭眼窩野 / 分子 / 心の再生 / 環境

Research Abstract

In rodents maternal-separation(MS), which is a neglect model, increases depression-and anxiety-like behaviors and hypothalamic-pituitary-adrenal responses to stress in adulthood. In this study, we analyzed what is the most sensitive behavioral indicator of MS to develop a novel treatment. We found that MS increased markedly the duration of leaning-against-wall behavior in open field test in rats, and that the leaning-against-wall behavior was a new high sensitive anxiety-like behavior by using anxiolytic.

Research Products

• [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats (2011)
  • Author(s): Tamatake M., Miyazaki N., Sudo K., Matsuda M., Sadakata T., Furuya A., Ichisaka S., Hata Y., Nakagawa C., Nagata K., Furuichi T., Katoh-Semba R.
  • Journal Title: J. Biol Chem Volume: 286 Pages: 21478-21478
  • Peer Reviewed
• [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. (2011)
  • Author(s): Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, Ichisaka S, Hata Y, Nakagawa C, Nagata K, Furuichi T, Katoh-Semba R
  • Journal Title: J. Biol. Chem. Volume: 286 Issue: 24 Pages: 21478-21487
  • DOI: 10.1074/jbc.m110.195859
  • Peer Reviewed
• [Journal Article] Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus (2009)
  • Author(s): Katoh-Semba, R. Kaneko, S. Kitajima, M. Tsuzuki, S. Ichisaka, Y. Hata, H. Yamada, N. Miyazaki, Y. Takahashi and K. Kato
  • Journal Title: Neuroscience Volume: 163 Pages: 352-361
  • Peer Reviewed
• [Journal Article] Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus. (2009)
  • Author(s): 仙波りつ子
  • Journal Title: Neuroscience 163 Pages: 352-361
  • Peer Reviewed
• [Presentation] 新生児期における母子分離経験はオープンフィールド試験における寄りかかり行動を増加させる (2011)
  • Author(s): 一坂吏志, 山本未希, 井久保樹子, 國石洋, 畠義郎
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 金沢(山代温泉瑠璃光)
  • Year and Date: 2011-09-27
• [Presentation] BDNF量はPKAあるいは神経活動の阻害によりp-CREBではなくMeCP2の変化を伴って変化する (2011)
  • Author(s): 山本未希, 一坂吏志, 仙波りつ子, 畠義郎
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 金沢(山代温泉瑠璃光)
  • Year and Date: 2011-09-27
• [Presentation] 新生児期における母子分離経験はオープンフィールド試験における寄りかかり行動を増加させる (2011)
  • Author(s): 一坂吏志, 山本未希, 井久保樹子, 國石洋, 畠義郎
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 山代温泉瑠璃光(石川県金沢市)
  • Year and Date: 2011-09-27
• [Presentation] BDNF量はPKAあるいは神経活動の阻害によりp-CREBではなくMeCP2の変化を伴って変化する (2011)
  • Author(s): 山本未希, 一坂吏志, 仙波りつ子, 畠義郎
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 山代温泉瑠璃光(石川県金沢市)
  • Year and Date: 2011-09-27
• [Presentation] Developmental changes of signaling molecules that regulate neurite outgrowth and myelination in the rat orbitofrontal cortex and visual cortex (2009)
  • Author(s): Ichisaka S, Miyahara M, Yamamoto A, Kojima K and Hata Y.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋(名古屋国際会議場)
  • Year and Date: 2009-09-17
• [Presentation] Developmenta changes of signaling molecules that regulate neurite outgrowth and myelination in the rat orbitofrontal cortex and visual cortex. (2009)
  • Author(s): 一坂吏志
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-09-17
• [Remarks] ホームページ
  • URL: http://www.med.tottori-u.ac.jp/neurobio/5980.html
• [Remarks]
  • URL: http://www.med.tottori-u.ac.jp/neurobio/5980.html