Functional analysis of ER stress sensor OASIS on the neuronal protection from the toxicity of kainic acid.

• Project/Area Number: 21700410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: University of Fukui
• Principal Investigator: CHIHARA Kazuyasu University of Fukui, 医学部, 講師 (00314948)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: グリア細胞 / 小胞体ストレス応答 / 小胞体ストレス / 神経細胞死 / カイニン酸

Research Abstract

Accumulated evidence clearly indicates that ER stress is involved in the development of neurodegenerative disorders including Alzheimer's disease. We have investigated the functions of ER stress sensor OASIS, which is specifically expressed in astrocyte. Recently, we established OASIS-/- mouse which shows the increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid. In this study, we found that OASIS expressed in astrocyte plays important roles on the expression and secretion of brain-derived neurotrophic factor (BDNF) to protect the neurons from the toxicity of kainic acid.

Research Products

• [Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation. (2011)
  • Author(s): Horiguchi T, Ishiguro N, Chihara K, Ogi K, Nakashima K, Sada K, Hori-Tamura N
  • Journal Title: Journal of Agricultural and Food Chemistry Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. (2010)
  • Author(s): Hino, S.Kondo, S.Yoshinaga, K.Saito, A.Murakami, T.Kanemoto, S.Sekiya, H.Chihara, K.Aikawa, Y.Hara, H.Kudo, T.Sekimoto, T.Funamoto, T.Chosa, E.Imaizumi, K.
  • Journal Title: J.Bone Miner.Metab. 28(2) Pages: 131-138
  • NAID: 10027207004
  • Peer Reviewed
• [Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る (2010)
  • Author(s): 千原一泰、定清直
  • Journal Title: 分子リウマチ治療 Volume: 3 Pages: 14-17
• [Journal Article] Regulation of ER molecular chaperone prevents bone loss in a murinemodel for osteoporosis. (2010)
  • Author(s): Hino S-I, Kondo S, Yoshinaga K, Saito A, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, Imaizumi K
  • Journal Title: Journal of Bone and Mineral Metabolism 28(2) Pages: 131-138
  • Peer Reviewed
• [Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. (2009)
  • Author(s): Murakami, T.Saito, A.Hino, S.Kondo,S.Kanemoto, S.Chihara, K.Sekiya, H.Tsumagari, K.Ochiai, K.Yoshinaga, K.Saitoh, M.Nishimura, R.Yoneda, T.Kou, I.Furuichi, T.Ikegawa, S.Ikawa, M.Okabe, M.Wanaka, A., Imaizumi, K.
  • Journal Title: Nat.Cell Biol. 11(10) Pages: 1205-1211
  • Peer Reviewed
• [Journal Article] Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainicacid in OASIS-deficient mice. (2009)
  • Author(s): Chihara, K.Saito, A.Murakami, T.Hino, S.Aoki, Y.Sekiya, H.Aikawa, Y.Wanaka, A., Imaizumi, K.
  • Journal Title: J.Neurochem 110(3) Pages: 956-965
  • Peer Reviewed
• [Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. (2009)
  • Author(s): Murakami T, Saito A, Hino S-I, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K.
  • Journal Title: Nature Cell Biology 11(10) Pages: 1205-1211
  • Peer Reviewed
• [Journal Article] Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. (2009)
  • Author(s): Chihara K, Saito A, Murakami T, Hino S-I, Aoki Y, Sekiya H, Aikawa Y, Wanaka A, Imaizumi K.
  • Journal Title: Journal of Neurochemistry 110(3) Pages: 956-965
  • Peer Reviewed
• [Presentation] アダプター蛋白質3BP2の点突然変異によるB細胞シグナル伝達への影響 (2010)
  • Author(s): 扇和弘、中島謙治、シュクラウパサナ、千原一泰、藤枝重治、定清直
  • Organizer: 第83回日本生化学会大会第33回日本分子生物学会年会合同年会
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-08
• [Presentation] アダプター蛋白質3BP2の点突然変異によるB細胞シグナル伝達への影響 (2010)
  • Author(s): 扇和弘, 中島謙治, シュクラウパサナ, 千原一泰, 藤枝重治, 定清直
  • Organizer: 第83回日本生化学会大会第33回日本分子生物学会年会合同学会
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-08
• [Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制 (2010)
  • Author(s): 中島謙治、竹内健司、千原一泰、堀田博、定清直
  • Organizer: 第83回日本生化学会大会第33回日本分子生物学会年会合同年会
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-07
• [Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制 (2010)
  • Author(s): 中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
  • Organizer: 第83回日本生化学会大会第33回日本分子生物学会年会合同学会
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-07
• [Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制 (2010)
  • Author(s): 中島謙治、竹内健司、千原一泰、堀田博、定清直
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島県
  • Year and Date: 2010-11-07
• [Presentation] アダプター蛋白質の点突然変異によるB細胞シグナル伝達の増強 (2010)
  • Author(s): 扇和弘、羽溪朋子、Upasana Shukla、千原一泰、藤枝重治、定清直
  • Organizer: 日本生化学会北陸支部第28回大会
  • Place of Presentation: 福井県
  • Year and Date: 2010-05-29
• [Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達の増強 (2010)
  • Author(s): 扇和弘, 羽溪朋子, Upasana Shukla, 千原一泰, 藤枝重治, 定清直
  • Organizer: 日本生化学会北陸支部第28回大会
  • Place of Presentation: 福井県
  • Year and Date: 2010-05-29
• [Presentation] Increased v ulnerability of py ramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice. (2009)
  • Author(s): Saito, A.Chihara, K.Murakami, T.Wanaka, A., Imaizumi, K.
  • Organizer: Society of Neuroscience 2009
  • Place of Presentation: シカゴ
  • Year and Date: 2009-10-19
• [Presentation] Increased vulnerability of pyramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice. (2009)
  • Author(s): Saito A, Chihara K, Murakami T, Wanaka A,, Imaizumi K.
  • Organizer: Society of Neuroscience
  • Place of Presentation: Chicago, USA.
  • Year and Date: 2009-10-19
• [Presentation] 小胞体ストレスセンサーOASISの欠損がカイニン酸による神経細胞死へ与える影響 (2009)
  • Author(s): 千原一泰、齋藤敦、村上智彦、青木悠里、和中明生、今泉和則
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県
  • Year and Date: 2009-09-17
• [Book] 関節リウマチ治療におけるSyk阻害薬の可能性を探る 3(4) (2010)
  • Author(s): 千原一泰、定清直
  • Publisher: 分子リウマチ治療(先端医学社)
• [Remarks] ホームページ等
  • URL: http://www.med.u-fukui.ac.jp/biseibutu/
• [Remarks]
  • URL: http://www.med.u-fukui.ac.jp/biseibutu/
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/anatomyl/