| Project/Area Number |
21700411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
YAMANE Masayuki 横浜市立大学, 医学研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | セマフォリン / 神経栄養因子 / シグナル伝播 / シグナル伝搬 |
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| Research Abstract |
Neurons are highly polarized cells with axon, dendrites, and cell body. These subcellular compartments need to communicate with each other. For example, signals received in distal axon travel long distances to reach the cell body and/or dendrites. In present study, I identified novel mechanism that the signal elicited by axon guidance molecule which is received at axonal growth cone, is transmitted towards cell body and dendrites. I further found that this novel signaling mediates dendritic morphology and maturation. Therefore I propose the model that the axon guidance signal which is received at distal axon simultaneously regulates dendritic development by this novel signal propagation mechanism.
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